Effect of continuous esketamine infusion on brain white matter microstructure in patients with major depression: A diffusion tensor imaging study

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成果类型：

期刊论文

作者：

Liu, Xiang;Wei, Zhipeng;Li, Lifeng;Li, Jiangping;Deng, Yingke;...

通讯作者：

Wu, GJ;Wan, X

作者机构：

[Liu, Yumeng; Liu, Xiang; Li, Lifeng; Peng, Dechang; Deng, Yingke; Li, Haijun] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Radiol,Jiangxi Prov Key Lab Precis Pathol & I, Nanchang, Jiangxi, Peoples R China.

[Wei, Zhipeng] Nanchang Univ, Affiliated Hosp 2, Dept Radiol, Jiangxi Med Coll, Nanchang, Jiangxi, Peoples R China.

[Li, Lifeng] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Radiol, Hengyang, Hunan, Peoples R China.

[Wu, Guojiang; Li, Jiangping; Wu, GJ] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Psychosomat Med, Nanchang, Jiangxi, Peoples R China.

[Wan, Xin; Wan, X] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept TCM, Nanchang, Jiangxi, Peoples R China.

通讯机构：

[Wan, X ; Wu, GJ ] N

Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Psychosomat Med, Nanchang, Jiangxi, Peoples R China.

Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept TCM, Nanchang, Jiangxi, Peoples R China.

语种：

英文

关键词：

Major depressive disorder;Esketamine;Tract-based spatial statistical analysis;Antidepressant

期刊：

Journal of Affective Disorders

ISSN：

0165-0327

年：

2025

卷：

372

页码：

173-181

DOI：

10.1016/j.jad.2024.12.002

基金类别：

National Natural Science Foundation of China [81860307]; Natural Science Foundation of Jiangxi Province, People's Republic of China [20202BABL216038]; Jiangxi Province Key Laboratory for Precision Pathology and Intelligent Diagnosis [2024SSY06281]; Key Research and Development Program of Jiangxi Province [20243BBI91031]; Science and technology project of Jiangxi Provincial Administration of Traditional Chinese Medicine [2023A0278]; Clinical Research Center For Medical Imaging in Jiangxi Province [20223BCG74001]

机构署名：

本校为其他机构

摘要：

Introduction Esketamine has demonstrated acute antidepressant effects in patients with major depressive disorder (MDD). This study investigated whether these effects associate with reversible white matter fiber integrity recovery using diffusion imaging. Esketamine has demonstrated acute antidepressant effects in patients with major depressive disorder (MDD). This study investigated whether these effects associate with reversible white matter fiber integrity recovery using diffusion imaging. Method Twenty patients with MDD and 20 healthy controls received 2-week esketamine treatment. Patients ...

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Effect of continuous esketamine infusion on brain white matter microstructure in patients with major depression: A diffusion tensor imaging study

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