期刊：
CURRENT DRUG TARGETS,2022年23(16):1526-1536 ISSN：1389-4501
作者机构：
[Xie, Yu-Xin; Yi, Guang-Hui; Yao, Hui; Peng, Jin-Fu] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target NewDrug, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.;[Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Int Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
drug targets;Ischemia-reperfusion injury;mitochondrial dysfunction;mitochondrial membrane;reactive oxygen species;targeted mitochondrial drugs
摘要：
Ischemia-reperfusion injury is a complex hemodynamic pathology that is a leading cause of death worldwide and occurs in many body organs. Numerous studies have shown that mitochondria play an important role in the occurrence mechanism of ischemia-reperfusion injury and that mitochondrial structural abnormalities and dysfunction lead to the disruption of the homeostasis of the whole mitochondria. At this time, mitochondria are not just sub-organelles to produce ATP but also important targets for regulating ischemia-reperfusion injury; therefore, drugs targeting mitochondria can serve as a new strategy to treat ischemia-reperfusion injury. Based on this view, in this review, we discuss potential therapeutic agents for both mitochondrial structural abnormalities and mitochondrial dysfunction, highlighting the application and prospects of targeted mitochondrial drugs in the treatment of ischemia-reperfusion injury, and try to provide new ideas for the clinical treatment of the ischemia-reperfusion injury.
期刊：
Archives of Pharmacal Research,2022年45(8):558-571 ISSN：0253-6269
通讯作者：
Yi, Lan
作者机构：
[Wei, Yuanyun; Yi, Lan] Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.;[Lin, Xiang; Wei, Yuanyun; Yi, Lan; Wei, Shuang; Gong, Yaqi; Chen, Yonglin; Qin, Hui; Yu, Yueqiu] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Key Lab Cellular Stress Biol, Hengyang Med Sch,Inst Cytol & Genet, Hengyang 421001, Hunan, Peoples R China.;[Cui, Jian] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Yan, Hongxia] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yi, Lan] I;Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.;Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
作者机构：
[Gu, Yongqing; Liang, Xinxin; Zhou, Shenghui; Ao, Xingkun] Univ South China, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.;[Li, Zhongqiu; Gu, Yongqing; Wang, Ping; Zhu, Jiaojiao; Xi, Tingting; Zhu, Maoxiang; Liang, Xinxin; Zhou, Shenghui; Li, Xueping; Yan, Ziyan; Ao, Xingkun; Li, Chao; Liu, Yuhao; Zhou, Ping-Kun] Acad Mil Med Sci, Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.;[Gu, Yongqing; Li, Xueping; Li, Chao; Gu, YQ] Shihezi Univ, Sch Life Sci, Shihezi 832003, Xinjiang, Peoples R China.;[Chen, Zhongmin] PLA Rocket Force Characterist Med Ctr, Beijing 100088, Peoples R China.;[Li, Zhongqiu; Gu, Yongqing] Shihezi Univ, Sch Med, Shihezi 832003, Xinjiang, Peoples R China.
通讯机构：
[Gu, YQ ] S;Shihezi Univ, Sch Life Sci, Shihezi 832003, Xinjiang, Peoples R China.;Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.
关键词：
Slug;PTEN;radio sensitization;RET;lncRNA
摘要：
Radioresistance is one of the key obstacles that may lead to the failure of cancer treatment. The underlying mechanisms of radioresistance remain largely unknown; however, increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in radiotherapy resistance of several cancers. In the present study, we demonstrated that radiation-elevated transcript (RET), a newly identified lnRNA, was highly expressed in cancer cells. Knockdown of RET significantly inhibited the proliferation and colony formation of cancer cells and markedly inhibited apoptosis. Furthermore, downregulation of RET in cancer cells significantly inhibited cell growth, decreased colony survival fractions, and promoted apoptosis in response to radiation treatment, indicating a role in radiation resistance. Moreover, RET knockdown significantly increased the expression of γ-H2AX, an indicator of DNA double strand damage, and reversed radiation-induced EMT, both of which contributed to its radiation resistance. In addition, a negative correlation was found between the expression of RET and PTEN. Rescue assays confirmed RET knockdown enhanced radiosensitivity of cancer cells by upregulating the expression of PTEN. Mechanistically, RET positively regulated Slug, a repressor of PTEN transcription, by acting as a molecular sponge of miR-3179. Our present study showed that RET conferred radioresistance by regulating miR-3179/Slug/PTEN axis, indicating that RET may be a potential target for the clinical application in cancer patients with radioresistance.
作者机构：
[Hu, Rui; Zhang, Zhen-Hua] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.
摘要：
An analysis of the forward-backward asymmetry (FBA) in the decay B-+/- -> (KKK +/-)-K-+/--K--/+ is carried out based on the LHCb data. It is found that the large FBA observed for the invariant mass of the K+ K- pair around 1.5 GeV can be explained by the interference of the amplitudes between the resonances with even and odd spins, where the former can be the spin-0 f(0)(1500) resonance plus a nonresonance s wave, while the latter is a spin-1 resonance which is probably rho(0)(1450). This is in contradiction with the conclusion of former experimental analysis [e.g., BABAR, Phys. Rev. D 85, 112010 (2012)], according to which the analysis showed no signal of spin-odd resonances at all when the invariant mass of the K+ K- pair was around 1.5 GeV. According to the analysis of the current paper the existence of the spin-odd resonances such as rho(0)(1450) is inevitable for the explanation of the large FBA in this region. The analysis also shows that the CP asymmetry of the decay channel B-+/- -> rho(0)(1450)K-+/- is about (-3.4 +/- 3.0)%. We suggest our experimental colleagues perform a closer analysis of this channel. We also suggest to perform the measurements of the FBAs (as well as the forward-backward CP asymmetry) in other three body decay channels of beauty and charmed mesons, as this is helpful for resonance analysis.
通讯机构：
[Gui-Gen Wang] S;[Man-Lin Tan] R;[Hui Ying Yang] P;Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore<&wdkj&>Shenzhen Key Laboratory for Advanced Materials, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Shenzhen 518055, PR China<&wdkj&>Research Institute of Tsinghua University in Shenzhen, Shenzhen 518055, PR China
摘要：
To achieve high-performance aqueous rechargeable alkaline batteries (ARABs), durable and high-rate anode materials should be developed. Bi-based materials have always been considered as promising anodes due to their enormous capacity, adequate negative operating voltage range, and three-electron redox characteristics. None-theless, the poor kinetics and low cycling stability of bi-based materials have severely limited their applications for ARABs. Here inspired by the unique structural characteristic of two-dimensional (2D) materials with a fast ion diffusion channel and relatively robust structure, 2D/2D Bi2O2S@rGO nanosheets were synthesized using a one-step hydrothermal process as the anode material for ARABs. At a current density of 1 A g-1, the as-optimized anodes exhibit a high specific capacity of 250.51 mAh g- 1. Using Bi2O2S@rGO NSs as the anode and (NiCo)9S8 as the cathode, the full cell exhibit a high energy density of 82.91 W h kg-1, a high power density of 7.59 kW kg-1, and excellent cycling stability, with a capacity retention rate of 92.74% after 5,000 cycles. This work could open up a way for environmentally friendly and high-performance anode materials.
关键词：
Rock mechanics;Jointed rock;Crack propagation;Uniaxial compression;Particle flow theory
摘要：
The existence of joints has a significant influence on the failure characteristics of rock mass. In this paper, based on two-dimensional (2D) particle flow code (PFC2D), uniaxial compression tests are conducted on the granite specimens with a single joint at different dip angles to investigate the evolution laws of macroscopic and mesoscopic failure characteristics. The results demonstrate that macro-mechanical characteristics of rock are influenced by the dip angle of the joint. The peak strength, peak deformation, and elastic modulus are positively correlated with the dip angle of the joint, while Poisson's ratio is negatively correlated. With the increase in the dip angle of the joint, mechanical characteristics of rock finally tend to be consistent with those of an intact rock specimen. In addition, when the dip angle of the joint is small, the rock specimens show obvious plastic characteristics before reaching the peak and there are multiple peaks being found on stress-strain curves. As the dip angle of the joint rises, the number of stress fluctuations gradually decreases and the curve near the peak becomes straighter and sharper. Moreover, the rock specimens exhibit more obvious brittle characteristics. The increase in the dip angle of the joint enhances the tendency of azimuth angle of microcracks to develop along the direction of the maximum principal stress. In the meanwhile, the distribution of the azimuth angle is gradually similar to that of microcracks in the intact specimen. With the rise of the joint dip angle, the failure modes of rock specimens change from tensile failure to shear failure to tensile failure, and finally tend to be consistent with the intact rock.
作者机构：
[Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Int Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Guang-Hui Yi] I;Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China
摘要：
Heart failure remains a considerable clinical and public health problem, it is the dominant cause of death from cardiovascular diseases, besides, cardiovascular diseases are one of the leading causes of death worldwide. The survival of patients with heart failure continues to be low with 45-60% reported deaths within five years. Apoptosis, necrosis, autophagy, and pyroptosis mediate cardiac cell death. Acute cell death is the hallmark pathogenesis of heart failure and other cardiac pathologies. Inhibition of pyroptosis, autophagy, apoptosis, or necrosis reduces cardiac damage and improves cardiac function in cardiovascular diseases. Pyroptosis is a form of inflammatory deliberate cell death that is characterized by the activation of inflammasomes such as NOD-like receptors (NLR), absent in melanoma 2 (AIM2), interferon-inducible protein 16 (IFI-16), and their downstream effector cytokines: Interleukin IL-1β and IL-18 leading to cell death. Recent studies have shown that pyroptosis is also the dominant cell death process in cardiomyocytes, cardiac fibroblasts, endothelial cells, and immune cells. It plays a crucial role in the pathogenesis of cardiac diseases that contribute to heart failure. This review intends to summarize the therapeutic implications targeting pyroptosis in the main cardiac pathologies preceding heart failure.
作者机构：
[Xie, Hailong; Xiang, Ting; Qiao, Muchuan] Univ South China, Canc Res Inst, Heng Yang Sch Med, Hunan Prov Key Lab Tumor Cellular Mol Pathol, Hengyang 421009, Peoples R China.;[Xie, Jiangbo] Cent South Univ, Affiliated Canc Hosp, Hunan Canc Hosp, Xiangya Sch Med, Changsha 410013, Peoples R China.;[Li, Zheng] Northwest Univ, Coll Life Sci, Lab Funct Glyc, Xian 710069, Peoples R China.
通讯机构：
[Zheng Li] L;[Hailong Xie] A;Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi’an 710069, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Hunan Province Key Laboratory of Tumor cellular Molecular Pathology, Cancer Research Institute, Heng yang School of Medicine, University of South China, Hengyang 421009, China
期刊：
Journal of Nuclear Materials,2022年563:153640 ISSN：0022-3115
通讯作者：
Yupeng Xie
作者机构：
[Chen, Min; Shi, Keyou; Li, Jiawei; Xie, Yupeng; Zhu, Ailian; Chen, Gaiyuan; Li, Xiangyang] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.;[Liu, Yong; Xie, Yupeng; Li, Xiangyang] Univ South China, Decommissioning Engn Technol Res Ctr Hunan Prov U, Hengyang 421001, Peoples R China.;[Liu, Yong] Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen, Peoples R China.
通讯机构：
[Yupeng Xie] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang Hunan 421001, PR China<&wdkj&>Decommissioning Engineering Technology Research Center of Hunan Province Uranium Tailings Reservoir, University of South China, Hengyang, 421001, PR China
摘要：
Oxyapatite (general formula: A(2)(I)A(8)(II) (BO4)(6)O-2) is a potential material for immobilization of nuclear waste. Here, a novel Sr2Nd8(SiO4)6O(2) glass-ceramics (GCs) derived from uranium tailings were synthesized by consecutive microwave sintering technology at 1200 degrees C for simultaneous immobilization of simulated bivalent fission product (FP) Sr and trivalent actinide (An(3+)) Nd. Sr and Nd were successfully immobilized into A(2)(I) and A(8)(II) acceptor sites of oxyapatite respectively, and glass structures. The phase evolution, microstructure, physical property, and radon exhalation of as-prepared sintered forms were systematically investigated by XRD, FT-IR, SEM-EDS, TEM, and RAD7 radon meter. The experimental results demonstrated that the ultimate solid solubility of Sr reached 25 wt.%, while Nd exceeded 30 wt.% at 1200 degrees C. Importantly, the solidified samples exhibited homogenous and dense microstructure, and the radon exhalation rate improved with the increase of pore. It was indicated that oxyapatite glass-ceramics could be a potential matrix for the simultaneous immobilization of bivalent FP and An(3+). (c) 2022 Elsevier B.V. All rights reserved.
作者机构：
[Huang, Shuangxiang; Cao, Zhaohui; Hu, Xiaobo; Tang, Cifei; Lu, Yang; Huang, Di] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.;[Cao, Zhaohui; Hu, Xiaobo; Peng, Cuiying; Tang, Cifei; Huang, Di] Univ South China, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Educ, Hengyang 421001, Peoples R China.
通讯机构：
[Xiaobo Hu] D;Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, University of South China, Hengyang 421001, China
期刊：
International Journal of Cardiology,2022年357:122 ISSN：0167-5273
通讯作者：
Chao-Ke Tang
作者机构：
[Tang, Chao-Ke; Li, Heng; Zeng, Guang-Gui] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Grade Excellent Doctor Class Hengyang Med Coll 20, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Chao-Ke Tang] I;Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, 2020 Grade Excellent Doctor Class of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
期刊：
Toxicology and Applied Pharmacology,2022年448:116092 ISSN：0041-008X
通讯作者：
Ling-Ling Zhu
作者机构：
[Geng, Ya-Nan; Fan, Ming] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders,Minist Sci & Technol, Beijing 100069, Peoples R China.;[Han, Ying; Zhao, Ming; Jiang, Xiu-Fang; Cheng, Xiang; Geng, Ya-Nan; Fan, Ming; Zhu, Ling-Ling] Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.;[Wang, Cheng-Bo; Yang, Jun-Li] Chinese Acad Sci, Lanzhou Inst Chem Phys LICP, CAS Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.;[Zhu, Ling-Ling] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China.;[Zhu, Ling-Ling] Anhui Med Univ, Coll Life Sci, Hefei 230032, Peoples R China.
通讯机构：
[Ling-Ling Zhu] B;Beijing Institute of Basic Medical Sciences, Beijing 100850, China<&wdkj&>Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China<&wdkj&>College of Life Sciences, Anhui Medical University, Hefei 230032, China<&wdkj&>Hengyang Medical School, University of South China, Hengyang 421001, China
作者机构：
[He, Shuya; Liu, Sisi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Song, Yuxin; He, Shuya; Tan, Huaxin; Liu, Sisi; Wang, Junyao] Univ South China, Sch Basic Med, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
通讯机构：
[Shuya He; Huaxin Tan] D;Department of Biochemistry and Molecular Biology, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Department of Biochemistry and Molecular Biology, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
摘要：
The rising incidence and severity of malignant tumors threaten human life and health, and the current lagged diagnosis and single treatment in clinical practice are inadequate for tumor management. Gold nanoclusters (AuNCs) are nanomaterials with small dimensions (<= 3 nm) and few atoms exhibiting unique optoelectronic and physicochemical characteristics, such as fluorescence, photothermal effects, radiosensitization, and biocompatibility. Here, the three primary functions that AuNCs play in practical applications, imaging agents, drug transporters, and therapeutic nanosystems, are characterized. Additionally, the promise and remaining limitations of AuNCs for tumor theranostic and combination therapy are discussed. Finally, it is anticipated that the information presented herein will serve as a supply for researchers in this area, leading to new discoveries and ultimately a more widespread use of AuNCs in pharmaceuticals.
