Therapeutic implications of targeting pyroptosis in Cardiac-related etiology of heart failure

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Habimana, Olive;Salami, Oluwabukunmi Modupe;Peng, Jinfu;Yi, Guang-Hui

通讯作者：

Guang-Hui Yi

作者机构：

[Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Int Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Guang-Hui Yi] I

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China

语种：

英文

关键词：

Cardiac fibroblasts;Cardiomyocytes;Heart failure;Inflammasome;Pyroptosis;Therapeutic implication

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2022

卷：

204

页码：

115235

DOI：

10.1016/j.bcp.2022.115235

基金类别：

This work was supported by the National Natural Sciences Foundation of China (No. 81770490 ), the Planned Science and Technology Project of Hunan Province, China (No. 2020JJ4535 ), and the Key Laboratory for Arteriosclerology of Hunan Province (Basic Medicine Sciences in University of South China).

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Heart failure remains a considerable clinical and public health problem, it is the dominant cause of death from cardiovascular diseases, besides, cardiovascular diseases are one of the leading causes of death worldwide. The survival of patients with heart failure continues to be low with 45-60% reported deaths within five years. Apoptosis, necrosis, autophagy, and pyroptosis mediate cardiac cell death. Acute cell death is the hallmark pathogenesis of heart failure and other cardiac pathologies. Inhibition of pyroptosis, autophagy, apoptosis, or...

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Therapeutic implications of targeting pyroptosis in Cardiac-related etiology of heart failure

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