GP-14 protects against severe hypoxia-induced neuronal injury through the AKT and ERK pathways and its induced transcriptome profiling alteration

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Geng, Ya-Nan;Zhao, Ming;Yang, Jun-Li;Cheng, Xiang;Han, Ying;...

通讯作者：

Ling-Ling Zhu

作者机构：

[Geng, Ya-Nan; Fan, Ming] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders,Minist Sci & Technol, Beijing 100069, Peoples R China.

[Han, Ying; Zhao, Ming; Jiang, Xiu-Fang; Cheng, Xiang; Geng, Ya-Nan; Fan, Ming; Zhu, Ling-Ling] Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.

[Wang, Cheng-Bo; Yang, Jun-Li] Chinese Acad Sci, Lanzhou Inst Chem Phys LICP, CAS Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.

[Zhu, Ling-Ling] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China.

[Zhu, Ling-Ling] Anhui Med Univ, Coll Life Sci, Hefei 230032, Peoples R China.

通讯机构：

[Ling-Ling Zhu] B

Beijing Institute of Basic Medical Sciences, Beijing 100850, China<&wdkj&>Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China<&wdkj&>College of Life Sciences, Anhui Medical University, Hefei 230032, China<&wdkj&>Hengyang Medical School, University of South China, Hengyang 421001, China

语种：

英文

关键词：

Gypenoside-14 (GP-14);Hypoxia;Neuronal Damage;Neuroprotection;Transcriptome Sequencing

期刊：

Toxicology and Applied Pharmacology

ISSN：

0041-008X

年：

2022

卷：

448

页码：

116092

DOI：

10.1016/j.taap.2022.116092

基金类别：

National Natural and Science Foundation of China [82072104, 81930054, 81430044]

机构署名：

本校为其他机构

摘要：

Gypenosides are major bioactive ingredients of G. pentaphyllum. In our previous study, we found that gypenosides had neuroprotective effects against hypoxia-induced injury. In the current study, we focused on the protective effects of gypenoside-14 (GP-14), which is one of the newly identified bioactive components, on neuronal injury caused by severe hypoxia (0.3% O2). The results showed that GP-14 pretreatment alleviated the cell viability damage and apoptosis induced by hypoxia in PC12 cells. Moreover, GP-14 pretreatment also attenuated prima...

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GP-14 protects against severe hypoxia-induced neuronal injury through the AKT and ERK pathways and its induced transcriptome profiling alteration

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