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Tumor-derived or non-tumor-derived exosomal noncodingRNAs and signaling pathways in tumor microenvironment

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成果类型:
期刊论文
作者:
Wu, Yiwen;Niu, Dun;Deng, Sijun;Lei, Xiaoyong;Xie, Zhizhong*;...
通讯作者:
Xie, Zhizhong;Yang, Xiaoyan
作者机构:
[Yang, Xiaoyan; Xie, Zhizhong; Niu, Dun; Deng, Sijun; Lei, Xiaoyong; Wu, Yiwen] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zhizhong Xie; Xiaoyan Yang] S
The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, PR China. Electronic address:
语种:
英文
关键词:
Cancer;Exosomes;Noncoding RNAs;Signaling pathways;TME
期刊:
International Immunopharmacology
ISSN:
1567-5769
年:
2022
卷:
106
页码:
108626
基金类别:
Hengyang City Science and Technology Planning Project [202150063473]; Scientific Research Project of Hunan Provincial Health Commission [202202044140]; Scientific Research Project of Hunan Provincial Education Department [21B0438]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2014-405]; Open Fund of Hunan Provincial Key Laboratory of Novel Antibody-Based Drug and its Intelligent Transport System [2020TP1044]; Reform and Development Fund of Hunan Colleges and Universities [202185]
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
The tumor microenvironment (TME) involved in multiple pathological processes of tumors is highly complex. Exosomes, as organelles, can be produced by some cells in the TME and have been verified as a special carriers and a key factor for communication between tumor and TME-associated cells. Noncoding RNAs (ncRNAs) involved in tumorigenesis and development have been demonstrated to be released into the TME by exosomes. However, the detailed regulatory functions of exosomal ncRNAs through signaling pathways in the TME are still unclear. In this r...

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