The significant role of the golgi apparatus in cardiovascular diseases
作者：
Lu, Liqun;Zhou, Qun;Chen, Zhe
* ;Chen, Linxi
* （ 期刊：
JOURNAL OF CELLULAR PHYSIOLOGY ,2018年233(4):2911-2919 ISSN：0021-9541
通讯作者：
Chen, Zhe;Chen, Linxi
作者机构：
[Chen, Linxi; Chen, Zhe; Lu, Liqun] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.;[Zhou, Qun] Hunan Univ Med, Coll Pharm, Huaihua, Peoples R China.
通讯机构：
[Chen, Z; Chen, LX] U;Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
关键词：
calcium;Article;blood vessel injury;cardiac graft rejection;cardiovascular disease;congestive cardiomyopathy;Golgi complex;heart arrhythmia;heart failure;heart muscle injury;heart ventricle hypertrophy;human;inflammation;leukemia;microtubule organizing center;priority journal;protein secretion;protein synthesis;pulmonary hypertension;ultrastructure
摘要：
The Golgi apparatus (GA) is a ribbon-like system of stacks which consist of multiple closely apposed flattened cisternae and vesicles usually localized in the juxta-nuclear area. As for the biological functions, the GA plays a major role in protein biosynthesis, post-translational modification, and sorting protein from ER to plasma membrane and other destinations. Structural changes and functional disorder of the GA is associated with various diseases. Moreover, increasing evidence revealed that swelling, poor development, and other morphological alterations of the GA are linked to cardiovascular diseases such as heart failure (HF), arrhythmia, and dilated cardiomyopathy. Furthermore, dysfunction of the GA is also related to cardiovascular diseases since the GA is extremely responsible for transport, glycosylation, biosynthesis, and subcellular distribution of cardiovascular proteins. This review gives a brief overview of the intricate relationship between the GA and cardiovascular diseases. In addition, we provide a further prospective that the GA may provide diagnosis reference for cardiovascular diseases, and changes in the ultrastructure and morphology of the GA such as swelling, poor development, and fragmentation may serve as a reliable index for cardiovascular diseases. © 2017 Wiley Periodicals, Inc.
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英文
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Involvement of the Warburg effect in non-tumor diseases processes
作者：
Chen, Zhe;Liu, Meiqing;Li, Lanfang
* ;Chen, Linxi
* （ 期刊：
JOURNAL OF CELLULAR PHYSIOLOGY ,2018年233(4):2839-2849 ISSN：0021-9541
通讯作者：
Li, Lanfang;Chen, Linxi
作者机构：
[Chen, Linxi; Li, Lanfang; Li, LF; Chen, Zhe; Liu, Meiqing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Li, LF; Chen, LX] U;Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
关键词：
animal;biological model;diseases;glycolysis;human;pH;Animals;Disease;Glycolysis;Humans;Hydrogen-Ion Concentration;Models, Biological
摘要：
Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic glycolysis, is extensively found in various cancers. Interestingly, increasing researchers show that Warburg effect plays a crucial role in non-tumor diseases. For instance, inhibition of Warburg effect can alleviate pulmonary vascular remodeling in the process of pulmonary hypertension (PH). Interference of Warburg effect improves mitochondrial function and cardiac function in the process of cardiac hypertrophy and heart failure. Additionally, the Warburg effect induces vascular smooth muscle cell proliferation and contributes to atherosclerosis. Warburg effect may also involve in axonal damage and neuronal death, which are related with multiple sclerosis. Furthermore, Warburg effect significantly promotes cell proliferation and cyst expansion in polycystic kidney disease (PKD). Besides, Warburg effect relieves amyloid β-mediated cell death in Alzheimer’s disease. And Warburg effect also improves the mycobacterium tuberculosis infection. Finally, we also introduce some glycolytic agonists. This review focuses on the newest researches about the role of Warburg effect in non-tumor diseases, including PH, tuberculosis, idiopathic pulmonary fibrosis (IPF), failing heart, cardiac hypertrophy, atherosclerosis, Alzheimer’s diseases, multiple sclerosis, and PKD. Obviously, Warburg effect may be a potential therapeutic target for those non-tumor diseases. © 2017.
语种：
英文
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Apelin/APJ system: A novel potential therapy target for kidney disease
作者：
Huang, Zhen;Wu, Lele
* ;Chen, Linxi
* （ 期刊：
JOURNAL OF CELLULAR PHYSIOLOGY ,2018年233(5):3892-3900 ISSN：0021-9541
通讯作者：
Wu, Lele;Chen, Linxi
（ 作者机构：
[Huang, Zhen; Wu, Lele; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.;[Huang, Zhen] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang, Peoples R China.
通讯机构：
[Wu, LL; Chen, LX] U;Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
关键词：
apelin/APJ system;fibrosis;kidney;kidney disease;transforming growth factor-β
摘要：
Apelin is an endogenous ligand of seven-transmembrane G protein-coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, kidney, and even in tumor tissues. Studies show that apelin mRNA is highly expressed in the inner stripe of kidney outer medulla, which plays an important role in process of water and sodium balance. Additionally, more studies also indicate that apelin/APJ system exerts a broad range of activities in kidney. Therefore, we review the role of apelin/APJ system in kidney diseases such as renal fibrosis, renal ischemia/reperfusion injury, diabetic nephropathy, polycystic kidney disease, and hemodialysis (HD). Apelin/APJ system can improve renal interstitial fibrosis by reducing the deposition of extracellular matrix. Apelin/APJ system significantly reduces renal ischemia/reperfusion injury by inhibiting renal cell death. Apelin/APJ system involves the progression of diabetic nephropathy (DN). Apelin/APJ system also predicts the process of polycystic kidney disease. Besides, apelin/APJ system prevents some dialysis complications in HD patients. And apelin/APJ system alleviates chronic kidney disease (CKD) by inhibiting vascular calcification (VC). Overall, apelin/APJ system plays diversified roles in kidney disease and may be a potential target for the treatment of kidney disease. © 2017 Wiley Periodicals, Inc.
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英文
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Apelin/APJ system: A bifunctional target for cardiac hypertrophy
作者：
Lu, Liqun;Wu, Di;Li, Lanfang
* ;Chen, Linxi
* （ 期刊：
International Journal of Cardiology ,2017年230:164-170 ISSN：0167-5273
通讯作者：
Li, Lanfang;Chen, Linxi
作者机构：
[Lu, Liqun; Wu, Di; Li, Lanfang; Chen, Linxi; Li, LF] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
通讯机构：
[Li, LF; Chen, LX] U;Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
关键词：
angiotensin II;apelin;apelin receptor;apelin;apelin receptor;APLN protein, human;APLNR protein, human;diabetes mellitus;disease association;exercise induced cardiomegaly;heart infarction;heart ventricle hypertrophy;human;hypertension;myocarditis;nonhuman;obesity;oxidative stress;protein expression;protein function;Review;animal;cardiac muscle cell;cardiomegaly;metabolism;oxidative stress;signal transduction;Animals;Apelin;Apelin Receptors;Cardiomegaly;Humans;Myocytes, Cardiac;Oxidative Stress;Signal Transduction
摘要：
Apelin acts as the endogenous ligand of G protein coupled receptors APJ. The apelin/APJ system is responsible for the occurrence and development of cardiovascular diseases. In recent years, apelin/APJ has been considered to play an important role in cardiac hypertrophy, but whether that role is beneficial or aggravating remains controversial. Apelin/APJ alleviates cardiac hypertrophy which is triggered by angiotensin II, oxidative stress and exercise. However, central administration of apelin induces cardiac hypertrophy. Peripheral administration of apelin also promotes the development of cardiac hypertrophy under non-pathological conditions. Furthermore, our laboratory discovers that apelin/APJ is able to induce hypertrophy of cardiomyocytes in vitro. The exact mechanism of apelin/APJ's dual effects in cardiac hypertrophy requires further study. In this paper, we review the controversies associated with apelin/APJ in cardiac hypertrophy and we elaborate the role of apelin/APJ in cardiac hypertrophy related-diseases including obesity, diabetes, hypertension, myocarditis and myocardial infarction. We conclude that further studies should emphasize more about the relationship between apelin/APJ and pathological hypertrophy especially in clinical patients. Moreover, apelin/APJ can be a promising therapeutic target for cardiac hypertrophy. © 2016
语种：
英文
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microRNA-128:肿瘤治疗新靶点
期刊：
临床肿瘤学杂志 ,2014年(9):849-853 ISSN：1009-0460
作者机构：
421001,湖南衡阳 南华大学药物药理研究所;[陈临溪; 曹建刚; 李赫宁] 南华大学
关键词：
胶质瘤;白血病;靶基因;调控机制
摘要：
微小RNA（miRNA）是体内一类长度为21～25个核苷酸的内源性非编码单链RNA，其主要通过完全或不完全互补结合至靶基因的3’非编码区而调控靶基因的表达。miRNA有多种类型，其中miR-128在多种疾病和正常组织中均不同程度的表达，具有广泛的调节作用。研究发现miR-128参与了神经胶质瘤、白血病、胃癌、肺癌及乳腺癌的发生过程，对细胞的分化、增殖、迁移和凋亡有重要作用。本文就miR-128在肿瘤中的研究进行详细阐述，以期为肿瘤的治疗提供新的靶点。
语种：
中文
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积极发挥大学班主任专业特长 提升专业人才素质培养——以药学专业人才培养为例
期刊：
中国高等医学教育 ,2014年(11):39-40 ISSN：1002-1701
作者机构：
南华大学药学与生物科学学院,湖南衡阳,421001;[陈临溪; 李兰芳; 贺冬秀; 单云丽] 南华大学
关键词：
班主任;药学;专业人才
摘要：
大学阶段是人生的飞跃,是成才道路上的重要阶段。拥有较强专业背景的大学班主任,通过多元化创新管理可以加强教师与学生的深层次交流以及拓展考研和就业途径,进而提升专业人才的素质培养。
语种：
中文
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心血管活性肽Apelin生物学功能研究进展
期刊：
心血管病学进展 ,2005年(S1):20-24 ISSN：1004-3934
作者机构：
南华大学药物药理研究所;南华大学药物药理研究所 湖南衡阳421001;[陈临溪; 李兰芳] 南华大学
关键词：
血管紧张素受体样受体;孤儿G蛋白偶联受体;血管紧张素Ⅰ转化酶2
摘要：
G-蛋白偶联受体是指一大类与G-蛋白偶联并参与和介导细胞外信号传递的跨膜蛋白，信号传导过程中与受体偶联的物质称为配体，对于不清楚内源性配体物质的G-蛋白偶联受体称为孤儿G一蛋白偶联受体。血管紧张素受体样受体是一种孤儿G-蛋白偶联受体。其内源性配体Apelin新近从牛胃抽提液中被分离出来，现发现apelin的功能涉及心血管系统，中枢神经系统，免疫系统等。Apelin在血管紧张素Ⅰ转化酶的同源酶血管紧张素Ⅰ转化酶2的作用下有活性形式转变成无活性的形式。现对apelin在心血管系统以及以其它众多生物学功能研究进展作一综述。
语种：
中文
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基因芯片技术在中医药研究中的应用
期刊：
浙江中西医结合杂志 ,2004年14(8):463-465 ISSN：1005-4561
作者机构：
南华大学药理学教研室,衡阳,421001;[陈临溪; 李兰芳] 南华大学
关键词：
基因芯片技术;中医药研究;DNA芯片;DNA微阵列;中医学
摘要：
基因芯片(gene chip),又称DNA芯片、DNA微阵列(DNA microarray).DNA芯片是将大量的DNA片段按预先设计的排列方式固定在载体表面,如硅片、玻片,并以此为探针,在一定的条件下与样品中待测的靶基因片段杂交,通过检测杂交后的信号实现对靶基因信息的快速检测.基因芯片可以分为很多种类,常见并广泛应用的有cDNA微点阵和寡核苷酸原位合成.基因芯片能对微量样品中的核酸序列进行检测和分析,其高通量、快速、并行化采集生物信息的特点更是优于其他传统的技术方法.基因芯片技术以一种系统、整体的方法进行研究,打破了"一种疾病、一种基因"的陈日模式,整体宏观上研究生物体基因的表达及功能.目前,基因芯片技术在中医学中的应用主要有:证、经络、藏象、针灸,以及中药的研制开发.
语种：
中文
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