期刊论文

Li, Lanfang;Chen, Linxi

英文

International Journal of Cardiology

0167-5273

2017

230

164-170

10.1016/j.ijcard.2016.11.215

This work was supported by the grants from the National Natural Science Foundation of China (81270420, 81470434, 81503074), the Construct Program of the Key Discipline in Hunan Province, the China Postdoctoral Science Foundation (2014M560647 and 2015T80875), Hunan Provincial Science and Technology Project (2015RS4040), Administration of Traditional Chinese Medicine of Hunan Province (201578), Health and Family planning commission of Hunan Province (B2015-48) and Zhengxiang Scholar Program of University of South China (2014-004).

本校为第一且通讯机构

Apelin acts as the endogenous ligand of G protein coupled receptors APJ. The apelin/APJ system is responsible for the occurrence and development of cardiovascular diseases. In recent years, apelin/APJ has been considered to play an important role in cardiac hypertrophy, but whether that role is beneficial or aggravating remains controversial. Apelin/APJ alleviates cardiac hypertrophy which is triggered by angiotensin II, oxidative stress and exercise. However, central administration of apelin induces cardiac hypertrophy. Peripheral administrati...