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The significant role of the Golgi apparatus in cardiovascular diseases

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成果类型:
期刊论文
作者:
Lu, Liqun;Zhou, Qun;Chen, Zhe*;Chen, Linxi*陈临溪
通讯作者:
Chen, Zhe;Chen, Linxi
作者机构:
[Chen, Linxi; Chen, Zhe; Lu, Liqun] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
[Zhou, Qun] Hunan Univ Med, Coll Pharm, Huaihua, Peoples R China.
通讯机构:
[Chen, Z; Chen, LX] U
Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
arrhythmia;cardiac hypertrophy;dilated cardiomyopathy;swelling;the Golgi apparatus
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2018
卷:
233
期:
4
页码:
2911-2919
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470434]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
The Golgi apparatus (GA) is a ribbon-like system of stacks which consist of multiple closely apposed flattened cisternae and vesicles usually localized in the juxta-nuclear area. As for the biological functions, the GA plays a major role in protein biosynthesis, post-translational modification, and sorting protein from ER to plasma membrane and other destinations. Structural changes and functional disorder of the GA is associated with various diseases. Moreover, increasing evidence revealed that swelling, poor development, and other morphological alterations of the GA are linked to cardiovascu...

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