作者机构：
[Deng, Chang'ai; Xiao, Xilin; Liao, Lifu; Zhou, Xin; Nie, Changming; He, Bo] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Peoples R China.
会议名称：
2015 International Conference on Materials,Environmental and Biological Engineering(MEBE 2015)
会议时间：
2015-03-28
会议地点：
中国广西桂林
关键词：
Staphylococcus aureus ssp. anaerobius (S. aureus);Penicillin G;Targeted drug delivery;Bone;Ti-Al intermetallic compounds porous material
摘要：
Bacterial infection is one of the most common problems after orthopedic implant surgery. If not prevented, bacterial infection can result in serious and life threatening conditions such as osteomyelitis. Thus, in order to reduce chances of such serious complication, patients are often subjected to antibiotic drug therapy for 6-8 weeks after initial surgery. The antibiotics are systemically delivered either intravenously, intramuscularly or topically. Systemic antibiotic delivery entails certain drawbacks such as systemic toxicity and limited bioavailability. Further, in order for the drug to be effective at the site of implantation, high doses are required, which can result in undesired side effects in patients. Thus, local antibiotic therapy is the preferred way of administering drugs. To that end, we have developed Ti-Al intermetallic compounds porous material for local delivery of antibiotics off-implant at the site of implantation. The Ti-Al intermetallic compounds porous materials were fabricated with reactively synthesizing. The fabrication strategies allow us to precisely control the dimension of aperture, thus enabling us to load different amounts of drugs and control the release rates. In this work we have fabricated Ti-Al intermetallic compounds porous material with 40 similar to 200 nm and 2 similar to 5 mu m apertures. We have loaded these tubes with 180, 360 and 540 mu g of penicillin G. The penicillin G release kinetics from the apertures and its effect on Staphylococcus aureus ssp. anaerobius (S. aureus) adhesion were investigated. Further, an osteosarcoma cell line called MG-63 was cultured on penicillin G-loaded aperture to evaluate the effect of Ti-Al intermetallic compounds porous material on cell functionality. Our results indicate that we can effectively fill the apertures with the drug and the drug eluting apertures significantly reduced bacterial adhesion on the surface. Also, there is enhanced MG-63 differentiation on apertures filled with penicillin G.
摘要：
A two dimensional coordination polymer with pseudo-Kagomé net [Cu3(btc)2(NH3)8(H2O)] was prepared from Cu(NO3)2·3H2O and 1, 3, 5-benzenetricarboxylic acid (btc) in ammonia aqua solution and was structurally characterized by X-ray diffraction. The magnetic susceptibility measurements, measured from 2 to 300 K, revealed a weak anti-ferromagnetic interaction between the CuII ions via the btc ligands.
摘要：
Nitroxides radicals are attractive tools for study in biochemistry and materials science. A polymorphic crystal of a nitroxide radical, 4,4,5,5-tetramethyl-2-phenylimidazoline-1-oxyl 1-oxide was prepared and structurally characterised. The compound crystallised in the monoclinic, space group C2/c with a = 11.170(6) Å, b = 10.417(5) Å, c = 10.995(5) Å, β = 108.059(9)°, V = 1216.3(10) Å, C13H 17N2O2, Mr = 233.29, Dc= 1.274 g cm-3, μ (MoKα) = 0.087 mm-1, Z = 4 and F(000) = 500. The structure was solved by direct methods and refined by least-squares techniques to the final R1 = 0.0626 and wR2 = 0.1679 for 1070 observed reflections (I > 2σ(I)). The magnetic susceptibility was measured.
