摘要：
Metallohydrogels are attractive biomaterials, whereas formation of a selective bimetallogel in aqueous solution has rarely been explored. In this study, we show that a phenylalanine derivative containing a 4-pyridine group can not only assemble to form single crystals with copper acetate, but also selectively generate a Cu-Ag bimetallohydrogel upon further addition of silver nitrate, which exhibits excellent multi-responsiveness. This study represents a novel example of a selective bimetallohydrogel in aqueous solution, which provides insights into the formation of a bimetallohydrogel and clues for future design of more functional biomaterials.
作者机构：
[He, Wei-Min; Cao, Zhong; Zhu, Qin] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Zhu, Qin] Hunan Univ Sci & Technol, Dept Chem, Xiangtan 411201, Peoples R China.
通讯机构：
[He, Wei-Min] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Green chemistry;Dual role;Quinoline N-oxides;Alkynes;Water
摘要：
Herein we summarized some clean preparation examples to emphasize the concept of dual roles design (or named as "two birds one stone strategy") in green and sustainable chemistry. In those examples, the reactants and/or solvent play dual roles rendering a cleaner organic preparation process. Consequently, both the chemical waste and manufacturing cost could be reduced. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
作者机构：
[Tan, Huaxin; Zhang, Peng; Liu, Zhonghua; Liang, Songping; Huang, Yazhou] Hunan Normal Univ, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Coll Life Sci, Changsha 410081, Hunan, Peoples R China.;[Tan, Huaxin; Xu, Jianghong; Ye, Zhongju; Xiao, Lehui; Chen, Bo] Hunan Normal Univ, Key Lab Phytochem R&D Hunan Prov, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China.;[Xiao, Lehui] Nankai Univ, State Key Lab Med Chem Biol, Coll Chem, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.;[Tan, Huaxin] Univ South China, Dept Biochem & Mol Biol, Sch Pharmaceut & Biol Sci, Hengyang 421001, Peoples R China.
通讯机构：
[Lehui Xiao] K;[Zhonghua Liu] T;The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China<&wdkj&>Key Laboratory of Phytochemical R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, 410081, China<&wdkj&>State Key Laboratory of Medicinal Chemical Biology College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin, 300071, China
会议名称：
19th World Congress of the International-Society-on-Toxinology (IST) / 11th Asia Pacific Congress of the International-Society-on-Toxinology (IST) / 13th Chinese Conference on Toxins and Medical Applications
摘要：
A biosorbent, 4-sulfonylcalix[6]arene modified Fe(3)O(4)@Aspergillus Niger (MFSC), was successfully prepared through a two-step route for the effective removal of uranium (U(VI)) from aqueous solutions with high selectivity. The structure of MFSC was characterized by FT-IR, SEM, XRD, TGA and VSM, respectively. The impacts of various experimental parameters were investigated in detail. The results indicated that the biosorption of U(VI) on MFSC was mainly attributed to the electrostatic attraction (91% within 8 hours for U(VI)). The adsorption kinetics and adsorption isotherm of U(VI) were found to follow the pseudo second-order model and to be fitted by the Langmuir model, respectively. The thermodynamic parameters revealed that the adsorption process was spontaneous and endothermic. The findings herein highlight the MFSC with high ability for removal of U(VI) from aqueous solutions.
作者：
Wang Ning;Pang Hongwei;Yu Shujun;Gu Pengcheng;Song Shuang;...
期刊：
化学学报,2019年77(2):143-152 ISSN：0567-7351
通讯作者：
Wang Hongqing;Wang Xiangke
作者机构：
[Wang Ning; Wang Hongqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421000, Peoples R China.;[Pang Hongwei; Yu Shujun; Wang Xiangke; Wang Ning; Song Shuang; Gu Pengcheng] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing 102206, Peoples R China.
通讯机构：
[Wang Hongqing] U;[Wang Xiangke] N;Univ South China, Sch Chem & Chem Engn, Hengyang 421000, Peoples R China.;North China Elect Power Univ, Coll Environm Sci & Engn, Beijing 102206, Peoples R China.
期刊：
Chemical Communications,2019年55(46):6610-6613 ISSN：1359-7345
通讯作者：
Lin, Ying-Wu
作者机构：
[Wei, Chuan-Wan; Liao, Fei; Lin, Ying-Wu; Du, Ke-Jie; Liu, Can] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.;[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.;[Gao, Shu-Qin; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
通讯机构：
[Lin, Ying-Wu] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
摘要：
The X-ray crystal structure of F43Y/T67R myoglobin revealed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, which represents a novel post-translational modification of heme proteins. Moreover, with the feature of a distal His-Arg pair, the designed artificial enzyme exhibited a peroxidase activity comparable to that of native peroxidases, such as the most efficient horseradish peroxidase.
摘要：
Using pomelo peel's pulp (PPP) as raw material, a new chemically modified PPP was prepared by the process of fermentation, cooking, freeze-drying, and so on. The adsorbent has been characterized by EDS, IR, BET and SEM. The factors of different adsorption conditions such as pH value, adsorption temperature, mass of adsorbent, adsorption time and initial concentration of UO2 (2+) were investigated. The adsorption mechanism was explored by adsorption thermodynamics and kinetics experiments. The results indicate that the pH value is 6.0, the dosage of adsorbent is 500 mg l(-1), the temperature is 50 degrees C and the adsorption time is 90 min, which is the best adsorption condition. When the initial concentration of UO2 (2+) is 35 mg l(-1), the adsorbed amount of uranyl ions by the modified PPP adsorbent can reach 42.733 mg g(-1), 26.8% higher than the adsorption amount of unmodified adsorbent (31.276 mg g(-1)), which is obviously enhanced. The kinetic and thermodynamic experiments show that the adsorption process is in good agreement with the pseudo second-order kinetics model, that it is an endothermic reaction, and the reaction is spontaneous. The adsorption process is entropy-dominated. The Freundlich adsorption isotherm can describe the adsorption process more accurately.
通讯机构：
[Lin, Ying-Wu] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
摘要：
Human neuroglobin (Ngb) forms an intramolecular disulfide bond between Cys46 and Cys55, with a third Cys120 near the protein surface, which is a promising protein model for heme protein design. In order to protect the free Cys120 and to enhance the protein stability, we herein developed a strategy by designing an additional disulfide bond between Cys120 and Cys15 via A15C mutation. The design was supported by molecular modeling, and the formation of Cys15-Cys120 disulfide bond was confirmed experimentally by ESI-MS analysis. Molecular modeling, UV-Vis and CD spectroscopy showed that the additional disulfide bond caused minimal structural alterations of Ngb. Meanwhile, the disulfide bond of Cys15-Cys120 was found to enhance both Gdn center dot HCl-induced unfolding stability (increased by similar to 0.64 M) and pH-induced unfolding stability (decreased by similar to 0.69 pH unit), as compared to those of WT Ngb with a single native disulfide bond of Cys46-Cys55. Moreover, the half denaturation temperature (T-m) of A15C Ngb was determined to be higher than 100 degrees C. In addition, the disulfide bond of Cys15-Cys120 has slight effects on protein function, such as an increase in the rate of O-2 release by similar to 1.4-fold. This study not only suggests a crucial role of the artificial disulfide in protein stabilization, but also lays the groundwork for further investigation of the structure and function of Ngb, as well as for the design of other functional heme proteins, based on the scaffold of A15C Ngb with an enhanced stability.
摘要：
The Aspergillus niger magnetic bioadsorbent ANFAN (amidoxime modified Nano-Fe3O4-Aspergillus niger, ANFAN) was prepared by amine oximation reaction with Aspergillus niger and nano-Fe3O4. The effects of initial pH value, adsorption time, adsorbent dosage, initial uranium concentration and coexisting ions on the adsorption of ANFAN for uranyl ion were studied in detail. The results showed that under the optimum adsorption conditions, the maximum adsorption efficiency of ANFAN for U(VI) solution amounted to 92.35%, and the maximum biosorption capacity could reach 23.38 mg/g. The kinetic data followed the pseudo-second-order model which indicated that the adsorption for uranium was mainly chemical activity on the surface of ANFAN. The adsorption equilibrium data fitted the Langmuir isotherm model well, which indicated that the adsorption of ANFAN for uranium was a single layer of chemical adsorption. Adsorption thermodynamics studies indicated that adsorption of ANFAN for uranium was a viable, spontaneous and endothermic process. The study provided a novel magnetic biosorbent with high adsorption capacity and a new method of adsorption for low concentrations of uranium.
