Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR-II Light.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wen, Mei;Ouyang, Jiang;Wei, Chuanwan;Li, Hui;Chen, Wansong*;...

通讯作者：

Chen, Wansong;Liu, You-Nian

作者机构：

[Wen, Mei; Chen, WS; Liu, You-Nian; Chen, Wansong; Li, Hui; Ouyang, Jiang] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.

[Wen, Mei; Chen, WS; Liu, You-Nian; Chen, Wansong; Ouyang, Jiang] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.

[Wei, Chuanwan] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Chen, WS; Liu, YN] C

Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.

Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.

语种：

英文

关键词：

anticancer;enzymes;immunotherapy;nanoparticles;oxidative stress

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2019

卷：

期：

页码：

17425-17432

DOI：

10.1002/anie.201909729

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21807117, 21636010]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3631]; State Key Laboratory of Powder Metallurgy, Central South University

机构署名：

本校为其他机构

院系归属：

化学化工学院

摘要：

Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems is to build antitumor immunity. However, immunotherapeutic efficacy is highly impeded by the immunosuppressive state of the tumors. Here a new strategy is presented, catalytic immunotherapy based on artificial enzymes. Cu2−xTe nanoparticles exhibit tunable enzyme-mimicking activity (including glutathione oxidase and peroxidase) under near-infrared-II (NIR-II) light. The cascade reactions catalyzed by the Cu2−xTe artifici...

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