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Cytotoxic polyhydroxy serratene triterpenoids from Lycopodium complanatum.

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成果类型:
期刊论文
作者:
Dong, Qiuzhu;Zou, Zhenxing;Jia, Xiaohui;Yu, Xia;Li, Jing;...
通讯作者:
Xu, Kangping
作者机构:
[Tan, Guishan; Dong, Qiuzhu; Zhou, Wenhao; Sun, Huihui; Wu, Wei; Li, Jing; Yu, Xia; Zou, Zhenxing; Xu, Kangping] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China.
[Tan, Guishan] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.
[Jia, Xiaohui] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[Xu, Kangping] C
Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China.
语种:
英文
关键词:
Cytotoxic activities;Lycopodium complanatum;Polyhydroxy serratene triterpenoids
期刊:
Bioorganic Chemistry
ISSN:
0045-2068
年:
2019
卷:
87
页码:
373-379
基金类别:
This research was financially supported by Postgraduates innovation subject of Central South University (No. 2018zzts872) and Key Project of Changsha Science and Technology Plan (No. kq1801072). We are appreciated support of Prof. GuoGen Liu for the NMR measurement and Prof. ShaoGang Liu for the HRESIMS measurement. There are no conflicts of interest to declare.
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
Phytochemical investigation of the 70% aqueous EtOH extract of Lycopodium complanatum led to six new polyhydroxy serratene triterpenoids (serrat A-F, 1–6), along with a known analogue (7). Their structures and configurations were elucidated by data analysis of HRESIMS, 1D and 2D NMR, in combination with comparisons of reported experimental spectroscopic data. All the isolates were evaluated cytotoxic activities against HepG2 cells, MCF-7 cells and series human lung cancer cell lines A549, Calu-6, NCI-H441, NCI-H226 and NCI-H1975. The results i...

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