Tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I: Role of ATP-binding membrane cassette transporter a1 and signal transducer and activator of transcription 3
作者：
Yin, Kai;Deng, Xiang;Mo, Zhong-Cheng;Zhao, Guo-Jun;Jiang, Jin;Cui, Li-Bao;Tan, Chun-Zhi;Wen, Ge-Bo;Fu, Yuchang;Tang, Chao-Ke*
期刊：
Journal of Biological Chemistry ,2011年286(16):13834-13845 ISSN：0021-9258
通讯作者：
Tang, Chao-Ke
作者机构：
[Zhao, Guo-Jun; Tan, Chun-Zhi; Tang, Chao-Ke; Wen, Ge-Bo; Yin, Kai; Mo, Zhong-Cheng; Jiang, Jin; Cui, Li-Bao] Univ S China, Affiliated Hosp 1, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr,Inst Cardiovasc Res, Hengyang 421001, Peoples R China.;[Wen, Ge-Bo; Yin, Kai] Univ S China, Affiliated Hosp 1, Dept Diagnost, Coll Med, Hengyang 421001, Peoples R China.;[Wen, Ge-Bo; Deng, Xiang] Univ S China, Affiliated Hosp 1, Dept Endocrinol & Metab, Hengyang 421001, Peoples R China.;[Fu, Yuchang] Univ Alabama, Dept Nutr Sci, Birmingham, AL 35294 USA.
通讯机构：
[Tang, Chao-Ke] Univ S China, Affiliated Hosp 1, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr,Inst Cardiovasc Res, Hengyang 421001, Peoples R China.
摘要：
Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the arterial intima. The activated macrophages secreted more pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, which promote the development of the disease. Apolipoprotein A-I (apoA-I), the major component of high density lipoprotein, is involved in reverse cholesterol transport of lipid metabolism. Recently, it has been found that apoA-I suppresses inflammation via repression of inflammatory cytokine expression;the mechanisms of the apoA-I-suppressive action, however, are not yet well characterized. In this study, we have for the first time found that apoA-I suppresses the expression of some inflammatory cytokines induced by lipopolysaccharide via a specific post-transcriptional regulation process, namely mRNA destabilization, in macrophages. Our further studies have also shown that AU-rich elements in the 3′-untranslated region of TNF-αmRNA are responsive to the apoA-I-mediated mRNA destabilization. The apoA-I-induced inflammatory cytokine mRNA destabilization was associated with increased expression of mRNA-destabilizing protein tristetraprolin through aJAK2/STAT3 signaling pathway-dependent manner. When blocking interaction of apoA-Iwith ATP-binding membrane cassette transporter A1 (ABCA1), a major receptor for apoA-Iin macrophages, it would almost totally abolish the effect of apoA-I on tristetraprolin expression. These results present not only a novel mechanism for the apoA-I-mediated inflammation suppression in macrophages but also provide new insights for developing strategies for modulating vascular inflammation and atherosclerosis. ©2011 by The American Society for Biochemistry and Molecular Biology, Inc.
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Existence and uniqueness of the solutions for a class of nonlinear fractional order partial differential equations with delay
作者：
Ouyang, Zigen
期刊：
Computers and Mathematics with Applications ,2011年61(4):860-870 ISSN：0898-1221
通讯作者：
Ouyang, ZG
作者机构：
[Ouyang, Zigen] Nanhua Univ, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Ouyang, Zigen] Nanhua Univ, Ctr Nucl Energy Econ & Management, Hengyang 421001, Peoples R China.
通讯机构：
[Ouyang, ZG] Nanhua Univ, Sch Math & Phys, Hengyang 421001, Peoples R China.
关键词：
Fractional order<&wdkj&>Partial differential equations<&wdkj&>Solution<&wdkj&>Existence<&wdkj&>Uniqueness<&wdkj&>Delay
摘要：
A class of nonlinear fractional order partial differential equations with delay c∂αu(x,t)∂tα=a(t)▵u(x,t)+f(t,u(x,τ1(t)), &mellip;,u(x,τl(t))),t∈[0,T0] be investigated in this paper, where cDαis the standard Caputo's fractional derivative of order 0≤α≤1, and l is a positive integer number, the function f is defined as f(t,u<inf>1</inf>,&mellip;,u<inf>l</inf>):R×R×&mellip;, ×R→R, and x∈Ωis a M dimension space. Using Lebesgue dominated convergence theorem, LeraySchauder fixed point theorem and Banach contraction mapping theorem, we obtain some sufficient conditions for the existence of the solutions of the above fractional order partial differential equations. ©2010 Elsevier Ltd. All rights reserved.
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英文
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An oscillation theorem for a class of second-order forced neutral delay differential equations with mixed nonlinearities
作者：
Zhong, Jichao;Ouyang, Zigen* ;Zou, Shuliang
期刊：
Applied Mathematics Letters ,2011年24(8):1449-1454 ISSN：0893-9659
通讯作者：
Ouyang, Zigen
作者机构：
[Zhong, Jichao; Ouyang, Zigen; Zou, Shuliang] Univ S China, Ctr Nucl Energy Econ & Management, Hengyang 421001, Peoples R China.;[Zhong, Jichao; Ouyang, Zigen] Univ S China, Sch Math & Phys, Hengyang 421001, Peoples R China.
通讯机构：
[Ouyang, Zigen] Univ S China, Ctr Nucl Energy Econ & Management, Hengyang 421001, Peoples R China.
关键词：
Oscillation<&wdkj&>Second-order<&wdkj&>Forced neutral delay differential equation<&wdkj&>Nonlinear<&wdkj&>Eventually positive solution
摘要：
A class of second-order forced neutral delay differential equation with mixed nonlinearities (r(t)|<sup>x′</sup>(t)+p<sup>x′</sup>(t- σ)|α-1(<sup>x′</sup>(t)+p<sup>x′</sup>(t-σ))) ′+<sup>q0</sup>(t)|x(<sup>τ0</sup>(t))|α-1x(<sup>τ0</sup>(t) )+∑i=1n<sup>qi</sup>(t)|x(<sup>τi</sup>(t))|<sup>βi</sup>-1x( <sup>τi</sup>(t))=e(t)sgn(x(t)) is investigated in this paper. Using a new method, we obtain some new sufficient conditions for the oscillation of the above equation, and some known oscillation criteria have been extended. ©2011 Elsevier Ltd. All rights reserved.
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英文
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Effect of magnetic islands on lower hybrid current drive in experimental advanced superconductor tokamak plasma with circular cross section
作者：
Li, Xinxia* ;Xiang, Nong;Shi, Xingjian
期刊：
Physics of Plasmas ,2014年21(9):092510 ISSN：1070-664X
通讯作者：
Li, Xinxia
作者机构：
[Li, Xinxia; Shi, Xingjian; Xiang, Nong] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Li, Xinxia] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
通讯机构：
[Li, Xinxia] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.
关键词：
discharges (electric), plasma instability, plasma magnetohydrodynamic waves, plasma simulation, plasma toroidal confinement, Tokamak devices, wave propagation
摘要：
The lower hybrid wave current drive (LHCD) in the presence of magnetic islands in Tokamak plasma with the circular cross section is studied numerically. The emergence of magnetic island is considered as a perturbation characterized by the perturbed magnetic flux near the resonant surface. By taking the perturbed magnetic field into account in the lower hybrid simulation code, the wave propagation, power deposition, and current drive are investigated using typical Experimental Advanced Superconductor Tokamak (EAST) L-and H-modes discharge parameters. The simulation results show that the wave propagation, power deposition, and current drive are significantly affected by the existence of magnetic island. Due to the H-mode pedestal, the effect of magnetic islands on the LHCD in EAST H-mode discharge is more significant than that in the L-mode discharge. (C) 2014 AIP Publishing LLC.
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英文
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Effects of alpha-particle irradiation on cell injury and the expressions of insulin sensitive-related genes in 3T3-L1 preadipocyte
作者：
Sun, Shao-Wei;Gong, Yong-Zhen;Tuo, Qin-Hui;Zhang, Xiao-Ying;Ke-Tang, Chao;Liao, Duan-Fang
期刊：
BioTechnology: An Indian Journal ,2013年8(4):543-550 ISSN：0974-7435
通讯作者：
Liao, D.-F.(dfliao66@aliyun.com)
作者机构：
[Tuo, Qin-Hui; Liao, Duan-Fang; Gong, Yong-Zhen; Sun, Shao-Wei] Hunan University of Chinese Medicine, Hanpu Science and Education District, 1# Xiangzui Road, Changsha 410208, Hunan, China;[Ke-Tang, Chao] Institute of Cardiovascular Disease, Life Science Research Center, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China;[Tuo, Qin-Hui; Ke-Tang, Chao; Liao, Duan-Fang; Gong, Yong-Zhen; Zhang, Xiao-Ying; Sun, Shao-Wei] Division of biochemistry, School of pharmacy and Life Science, University of South China, 28# Changsheng West Road, Hengyang 421001, Hunan, China;[Zhang, Xiao-Ying] Division of Pharmacoproteomics, School of pharmacy and Life Science, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China
摘要：
Exposure of cells to densely ionizing radiation can initiate a series of molecular and cellular events, which result in the gain and loss of functions in critical regulatory genes and cellular damage. In the present study, alpha-particle radiation-induced insulin resistance and toxic injury to 3T3- L1 preadipocyte were observed, and the mechanism underlying the action was investigated. 3T3-L1 preadipocytes were irradiated by different doses of alpha-particle at 0Gy , 0.3Gy , 0.6Gy , 1.0Gy , 1.5Gy , 2.0Gy , and 4.0Gy . Cloning efficiency was investigated to evaluate the cellular toxic effect of alpha-particle irradiation on cellular viability. Cytokinesis-block micronucleus technique ( CB-MNT ) and single-cell comet assay COMET assay were used to observe alpha-particle irradiation-induced DNA damage. Expression of caveolin-1, IRS-1 (insulin receptor substrate-1 ) and GLUT-4 ( glucose transporter-4 ) were analyzed by western blot and Reverse-transcription PCR (RT-PCR). Alpha-particle irradiation inhibited cloning efficiency, and increased micronucleus cells and the DNA damage in 3T3-L cells in a dose-dependent manner. Alpha-particle irradiation decreased the mRNA expression of GLUT-4 and IRS-1, and inhibited the protein expression of caveolin-1. The present results indicate that alphaparticle irradiation induced toxic injury and insulin resistance in 3T3-L1 preadipocyte, which might be associated with inhibition of GLUT-4 and IRS-1 expression by down-regulating caveolin-1. ©2013 Trade Science Inc. - INDIA.
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英文
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