Effects of alpha-particle irradiation on cell injury and the expressions of insulin sensitive-related genes in 3T3-L1 preadipocyte

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成果类型：

期刊论文

作者：

Sun, Shao-Wei;Gong, Yong-Zhen;Tuo, Qin-Hui;Zhang, Xiao-Ying;Ke-Tang, Chao;...

通讯作者：

Liao, D.-F.(dfliao66@aliyun.com)

作者机构：

[Tuo, Qin-Hui; Liao, Duan-Fang; Gong, Yong-Zhen; Sun, Shao-Wei] Hunan University of Chinese Medicine, Hanpu Science and Education District, 1# Xiangzui Road, Changsha 410208, Hunan, China

[Ke-Tang, Chao] Institute of Cardiovascular Disease, Life Science Research Center, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China

[Tuo, Qin-Hui; Ke-Tang, Chao; Liao, Duan-Fang; Gong, Yong-Zhen; Zhang, Xiao-Ying; Sun, Shao-Wei] Division of biochemistry, School of pharmacy and Life Science, University of South China, 28# Changsheng West Road, Hengyang 421001, Hunan, China

[Zhang, Xiao-Ying] Division of Pharmacoproteomics, School of pharmacy and Life Science, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China

通讯机构：

[Liao, D.-F.] H

Hunan University of Chinese Medicine, 1# Xiangzui Road, Changsha 410208, Hunan, China

语种：

英文

关键词：

3T3-L1 cell;Alpha-particle;GLUT-4;Irradiated injury;IRS-1

期刊：

BioTechnology: An Indian Journal

ISSN：

0974-7435

年：

2013

卷：

期：

页码：

543-550

机构署名：

本校为其他机构

院系归属：

国防科学技术学院

化学化工学院

医学院

药学与生物科学学院

摘要：

Exposure of cells to densely ionizing radiation can initiate a series of molecular and cellular events, which result in the gain and loss of functions in critical regulatory genes and cellular damage. In the present study, alpha-particle radiation-induced insulin resistance and toxic injury to 3T3- L1 preadipocyte were observed, and the mechanism underlying the action was investigated. 3T3-L1 preadipocytes were irradiated by different doses of alpha-particle at 0Gy , 0.3Gy , 0.6Gy , 1.0Gy , 1.5Gy , 2.0Gy , and 4.0Gy . Cloning efficiency was investigated to evaluate the cellular toxic effect of...

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Effects of alpha-particle irradiation on cell injury and the expressions of insulin sensitive-related genes in 3T3-L1 preadipocyte

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