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Tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I: Role of ATP-binding membrane cassette transporter a1 and signal transducer and activator of transcription 3

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成果类型:
期刊论文
作者:
Yin, Kai;Deng, Xiang;Mo, Zhong-Cheng;Zhao, Guo-Jun;Jiang, Jin;Cui, Li-Bao;Tan, Chun-Zhi;Wen, Ge-Bo;Fu, Yuchang;Tang, Chao-Ke
通讯作者:
Tang, C.-K.
作者机构:
[Yin, Kai] Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, 421001, China
通讯机构:
[Tang, Chao-Ke] Univ S China, Affiliated Hosp 1, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr,Inst Cardiovasc Res, Hengyang 421001, Peoples R China.
Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, China
语种:
英文
关键词:
Activated macrophages - Apolipoprotein A-I - Apolipoprotein A-I (apoA-I) - ATP-binding - AU-rich elements - Cholesterol transport - Cytokine expression - Cytokines - Developing strategy - High density lipoprotein - Inflammatory cytokines - Inflammatory disease - Lipid metabolisms - Lipopolysaccharides - mRNA expression - Post-transcriptional regulations - Signal transducers - Signaling pathways - Tristetraprolin - Tumor necrosis factors - Untranslated regions
期刊:
Journal of Biological Chemistry
ISSN:
0021-9258
年:
2011
卷:
286
期:
16
页码:
13834-13845
基金类别:
National Natural Sciences Foundation of China [30470720, 81070220]; Post-doctoral Sciences Foundation of China [2005037157]; Hunan Provincial Natural Sciences Foundation of China [10JJ9019, 06jj5058]; Hunan Post-graduate Innovative Project [CX2010B379]; Science and Technology Department Funds of Heng Yang of Hunan Province [2010kj17]
机构署名:
本校为第一且通讯机构
院系归属:
国防科学技术学院
医学院
药学与生物科学学院
摘要:
Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the arterial intima. The activated macrophages secreted more pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, which promote the development of the disease. Apolipoprotein A-I (apoA-I), the major component of high density lipoprotein, is involved in reverse cholesterol transport of lipid metabolism. Recently, it has been found that apoA-I suppresses inflammation via repression of inflammatory cytokine expression;the mechanisms of the apoA-I-suppressive action, however, are not yet well characterized. In this study, we have for the first time found that apoA-I suppresses the expression of some inflammatory cytokines induced by lipopolysaccharide via a specific post-transcriptional regulation process, namely mRNA destabilization, in macrophages. Our further studies have also shown that AU-rich elements in the 3′-untranslated region of TNF-αmRNA are responsive to the apoA-I-mediated mRNA destabilization. The apoA-I-induced inflammatory cytokine mRNA destabilization was associated with increased expression of mRNA-destabilizing protein tristetraprolin through aJAK2/STAT3 signaling pathway-dependent manner. When blocking interaction of apoA-Iwith ATP-binding membrane cassette transporter A1 (ABCA1), a major receptor for apoA-Iin macrophages, it would almost totally abolish the effect of apoA-I on tristetraprolin expression. These results present not only a novel mechanism for the apoA-I-mediated inflammation suppression in macrophages but also provide new insights for developing strategies for modulating vascular inflammation and atherosclerosis. ©2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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