作者机构：
[Tang, Zan-Mei; Deng, Jian; Zheng, Xue-Mei; Wang, Shao-Hua] Univ South China, Women & Children Hlth Inst Futian, Neonatal Intens Care Unit, 2002 Jintian South Rd, Shenzhen 518045, Guangdong, Peoples R China.
通讯机构：
[Wang, Shao-Hua] U;Univ South China, Women & Children Hlth Inst Futian, Neonatal Intens Care Unit, 2002 Jintian South Rd, Shenzhen 518045, Guangdong, Peoples R China.
关键词：
alveolar epithelium type II cells;alveolar epithelium.;calcitonin gene-related peptide;hyperoxia exposure
期刊：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,2022年38(9):848-857 ISSN：1607-551X
通讯作者：
Hong Huang<&wdkj&>Ze-Cheng Hu
作者机构：
[Shen, Ying-Ying; Xu, Jia-Chi; Fan, Shan-Ji; Hu, Ze-Cheng; Li, Yue-Hua; Huang, Hong] Univ South China, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;[Cui, Ying] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang, Hunan, Peoples R China.
通讯机构：
[Hong Huang; Ze-Cheng Hu] T;The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
关键词：
breast cancer;CASC9;invasion;SOX4;STAT3
摘要：
Numerous long noncoding RNAs (lncRNAs) are abnormally expressed in breast cancer (BC), but the underlying mechanisms remain large unknown. Here, we aimed to investigate the functions and mechanisms of lncRNA cancer susceptibility candidate 9 (CASC9) in BC. Western blotting and quantitative real-time PCR (qRT-PCR) were performed to assess gene and protein expression, respectively. The proliferative and metastatic abilities of BC cells were tested by cell counting kit-8 and transwell assays, respectively. The formation of lymphatic vessels was detected by tube formation assay. Chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were performed to verify molecular interactions. CASC9 was found to be highly expressed in BC tissues and cell lines, and ectopic overexpression was positively associated with tumor volume, TNM stage, and lymph node metastasis. In addition, CASC9 silencing significantly inhibited the proliferation and invasion of BC cells, as well as BC-associated invasion and formation of lymphatic vessels of human dermal lymphatic endothelial cells. Mechanical studies demonstrated that CASC9 could be transcriptionally activated by STAT3 and elevate SOX4 expression by enhancing the acetylation of its promoter region. Our results illustrated that STAT3-activated CASC9 served as a tumor-promoting gene involved in promoting BC invasion and BC-associated formation of lymphatic vessels by upregulating SOX4 through altering H3K27ac level. This finding elucidated a new underlying network of CASC9 in the metastasis of BC.
作者机构：
[Wang, Zhen; Shi, Tao; Wang, Xiaodong; Yin, Gaofeng] Lanzhou Univ, Sch Pharm, 199 West Donggang Rd, Lanzhou 730000, Peoples R China.;[Liu, Linyi; Wang, Zhen; Xiong, Yongxia] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Dr. Linyi Liu; Prof. Dr. Zhen Wang] S;School of Pharmaceutical Science, Hengyang Medical School, University of South China, No. 28 West Changsheng Road, Hengyang, 421001, Hunan China<&wdkj&>School of Pharmacy, Lanzhou University, No. 199 West Donggang Road, Lanzhou, 730000 China<&wdkj&>School of Pharmaceutical Science, Hengyang Medical School, University of South China, No. 28 West Changsheng Road, Hengyang, 421001, Hunan China
作者：
Chen, Y. Y.;Zhang, Y. P.;Liu, Y.;Liu, J. C.;Guo, C.*;...
期刊：
Journal of Instrumentation,2022年17(2):P02003 ISSN：1748-0221
通讯作者：
Guo, C.
作者机构：
[Tang, Q.; Chen, Y. Y.; Liu, Y.; Qiu, S. K.] Univ South China, Sch Nucl Sci & Technol, Hengyang, Peoples R China.;[Guo, C.; Zhang, Y. P.; Zhang, P.; Liu, J. C.; Yang, C. G.] Chinese Acad Sci, Inst High Energy Phys, Expt Phys Div, Beijing, Peoples R China.;[Guo, C.; Zhang, Y. P.; Zhang, P.; Liu, J. C.; Yang, C. G.] Univ Chinese Acad Sci, Sch Phys, Beijing, Peoples R China.
通讯机构：
Experimental Physics Division, Institute of High Energy Physics, Chinese Academy of Science, Beijing, China
关键词：
Dark Matter detectors (WIMPs, axions, etc.);Heavy-ion detectors;Neutrino detectors
作者机构：
[Wei, Yuezhou; Hamza, Mohammed F.] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Abu Khoziem, Hanaa A.; Khalafalla, Mahmoud S.; Zaki, Doaa, I; Hamza, Mohammed F.; Abdellah, Walid M.] Nucl Mat Author, POB 530, Cairo 11728, Egypt.;[Althumayri, Khalid] Taibah Univ, Coll Sci, Dept Chem, Al Madinah Al Munawarah 30002, Saudi Arabia.;[Wei, Yuezhou] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Shanghai 200240, Peoples R China.
通讯机构：
[Mohammed F. Hamza; Yuezhou Wei] A;Authors to whom correspondence should be addressed.<&wdkj&>School of Nuclear Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang 421001, China<&wdkj&>Nuclear Materials Authority, POB 530, El-Maadi, Cairo 11728, Egypt
关键词：
uranium;metal decontamination;hydrogel;uptake kinetics;sorption isotherms;recovery of heavy metal
摘要：
The development of new materials based on biopolymers (as renewable resources) is substantial for environmental challenges in the heavy metal and radionuclide ions removal contaminations. Functionalization of chitosan with sulfonic groups was achieved for improving the uranium sorption, not only from slightly acidic leachate, but also for the underground water. The prepared hydrogel based on chitosan was characterized by series of analysis tools for structure elucidation as FTIR spectroscopy, textural properties using nitrogen adsorption method, pH(PZC) (by pH-drift method), thermogravimetric analysis (TGA), SEM, and SEM-EDX analyses. The sorption was performed toward uranium (VI) ions for adjustment of sorption performances. The optimum sorption was performed at pH 4 (prior to the precipitation pH). The total sorption was achieved within 25 min (relatively fast kinetics) and was fitted by pseudo-first order rate equation (PFORE) and resistance to intraparticle diffusion equation (RIDE). The maximum sorption capacity was around 1.5 mmol U g(-1). The sorption isotherms were fitted by Langmuir and Sips equations. Desorption was achieved using 0.3 M HCl solution and the complete desorption was performed in around 15 min of contact. The sorption desorption cycles are relatively stable during 5 cycles with limit decreasing in sorption and desorption properties (around 3 +/- 0.2% and 99.8 +/- 0.1%, respectively). The sorbent was used for removal of U from acid leachate solution in mining area. The sorbent showed a highly performance for U(VI) removal, which was considered as a tool material for radionuclides removing from aquatic medium.
作者机构：
[Chen, Yang; Wang, Qian] Fujian Normal Univ, Sch Econ, Fuzhou 350117, Fujian, Peoples R China.;[Wang, Qian; Guan, Heshan] Univ South China, Sch Econ & Management & Law, Hengyang 421001, Peoples R China.;[Lyulyov, Oleksii; Pimonenko, Tetyana] Sumy State Univ, Dept Mkt, UA-40007 Sumy, Ukraine.
通讯机构：
[Tetyana Pimonenko] D;Department of Marketing, Sumy State University, 40007 Sumy, Ukraine<&wdkj&>Author to whom correspondence should be addressed.
关键词：
technological innovation efficiency;SBM-Tobit model;kernel density estimation
作者机构：
[Song, Baixing] Univ South China, Coll Civil Engn, Hengyang 421001, Peoples R China.;[Hu, Xiang; Liu, Songhui] Henan Polytech Univ, Sch Mat Sci & Engn, Jiaozuo 454003, Peoples R China.;[Shi, Caijun; Hu, Xiang] Hunan Univ, Coll Civil Engn, Int Sci & Technol Innovat Ctr Green & Adv Civil En, Key Lab Green & Adv Civil Engn Mat & Applicat Tech, Changsha 410082, Peoples R China.
通讯机构：
[Caijun Shi] K;Key Laboratory for Green & Advanced Civil Engineering Materials and Application Technology of Hunan Province, International Science and Technology Innovation Centre for Green & Advanced Civil Engineering Materials of Hunan Province, College of Civil Engineering, Hunan University, Changsha, 410082, China
关键词：
Chloride binding;Chloride salt type;Early CO2 curing;fly ash;GGBS
作者机构：
[Luo, Zeyu; Wen, Feng; Li, Junjun; Long, Xingxing; Cao, Yixiong; Luo, Cong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hematol, Hengyang, Peoples R China.
通讯机构：
[Cong Luo] D;Department of Hematology, The 1st Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China
期刊：
World Neurosurgery,2022年157:E301-E307 ISSN：1878-8750
通讯作者：
Peng, Jun
作者机构：
[Liu, Shucheng] Univ South China, Affiliated Hosp, Dept Urol, Hengyang City, Peoples R China.;[Peng, Jun] Univ South China, Affiliated Hosp, Dept Neurol, Hengyang City, Peoples R China.;[Wang, Yilin] Univ South China, Affiliated Nanhua Hosp, Dept Crit Care Med, Hengyang City, Peoples R China.;[Gao, Bin] Univ South China, Affiliated Nanhua Hosp, Dept Endocrinol, Hengyang City, Peoples R China.
通讯机构：
[Peng, Jun] U;Univ South China, Affiliated Hosp, Dept Neurol, Hengyang City, Peoples R China.
摘要：
BACKGROUND: The aim of this study was to develop and validate a nomogram for predicting the risk of venous thromboembolism among critically ill patients with primary intracerebral hemorrhage. METHODS: Patients aged ≥ 18 years with primary intracerebral hemorrhage within 24 hours of onset were screened from January 2019 to April 2021. Univariate and multivariate logistic regression analysis were performed to screen out the independent predictors that were significantly associated with venous thromboembolism. A nomogram was constructed based on the results of a multivariate regression analysis. Discrimination and calibration were used to evaluate its performance. A decision curve analysis was used to assess its clinical utility. RESULTS: A total of 369 patients were enrolled in this study. The nomogram included three predictors from the regression analysis: D-Dimer value, National Institute of Health Stroke Scale score and Glasgow Coma Scale score on admission. The area under the receiver operating characteristic curves was 0.794, indicating good discrimination of the nomogram. The nomogram demonstrated calibration curves with slight deviation from the ideal predictions. Decision curve analysis showed that the prediction nomogram was clinically useful. CONCLUSIONS: The nomogram composed of D-Dimer value, National Institute of Health Stroke Scale score and Glasgow Coma Scale score on admission can predict the risk of venous thromboembolism in critically ill patients with intracerebral hemorrhage accurately.
摘要：
BACKGROUND: We aim to make a systematic evaluation of the clinical efficacy of acupuncture in the treatment of cognitive impairment after stroke, to provide evidence-based medical evidence for clinical practice. METHODS: We searched all the randomized controlled trials of China National Knowledge Infrastructure, Wan fang data knowledge service platform, VIP Chinese periodical service platform full-text Journal Database, Chinese Biomedical Literature Database, Cochrane Library Database, and PubMed Database about acupuncture treatment of post-stroke cognitive impairment (PSCI). Two researchers independently screened the literature and extracted the data according to the inclusion and exclusion criteria. The bias risk assessment manual of Cochrane collaboration Network was used to evaluate the bias risk, and all data were analyzed by Stata16.0. RESULTS: Fourteen articles were included, with a total of 2402 patients. Meta-analysis showed that acupuncture combined with routine therapy could significantly reduce the score of cognitive impairment symptoms compared with the control group. The mini-mental state examination scale (MMSE) score (weighted mean difference [WMD] = 3.23, 95% confidence interval [CI]: 1.89-4.56, P < .01), Montreal cognitive assessment scale (MoCA) score (WMD = 3.41, 95% CI: 0.93-5.89, P < .01), Barthel index of activities of daily living (MBI) score (WMD = 4.59, 95% CI: 1.43-7.75, P < .01), and Lowenstein assessment scale (LOTCA) score (WMD = 8.60, 95% CI: 6.32-10.89, P = .00) were significantly improved in the patients receiving group acupuncture combined with routine therapy. CONCLUSION: Acupuncture combined with routine therapy seems to be more effective than conventional therapy alone in the treatment of PSCI. However, the differences between different acupuncture types need to be clarified in more high-quality randomized controlled trials.
通讯机构：
[Zhongran Dai] K;Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, China
摘要：
Herein, calcium peroxide modified mesoporous silica (CPMS) was successfully synthesized by a facile strategy and used for simultaneous adsorption and immobilization of U(VI) from uranium-containing wastewater. The batch uranium adsorption experiments reveal excellent adsorption performance of CPMS over a wide pH value. In comparison to calcium peroxide and mesoporous silica, the CPMS showed a great improvement in the removal capacity of uranium. As well, the pseudo-second-order model and Langmuir isotherm model provided a well description of adsorption kinetics and isotherm, respectively, which suggested the monolayer chemisorption governed the adsorption of CPMS for U(VI). In addition, the Langmuir isotherm model calculated the maximum adsorption capacity of CPMS for U(VI) up to 613.50 mg/g. Based on mechanistic studies of XPS, FT-IR, TEM and XRD, U(VI) is predominantly removed through synergistic adsorption of U(VI) by mesoporous silicon and immobilization of U(VI) by calcium peroxide as (UO2)O-2 center dot 2 H2O (metastudtite). Furthermore, the efficient removal ability of CPMS for U(VI) in uranium tailings leachate was confirmed by column test, the U(VI) con-centration of uranium tailings leachate can be reduced from 180.4 mu g/L to 2.3 mu g/L in 1895.2-bed volumes, which was well lower than the standard limit of WHO for U(VI) concentration in drinking water. This research provides a feasible approach and new idea for the efficient treatment of radioactive wastewater.
作者机构：
[Liu, MengSi; Sun, Zhen] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;[Sun, Zhen] Univ South China, Hengyang Med Sch, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Sun, Z.] H;Hengyang Medical School, University of South China, No. 28 Changsheng West Road, Hunan Province, Hengyang City, China
关键词：
*bridging therapy;*chimeric antigen receptor T cells;*efficacy;*radiation therapy;*safety;*systematic therapy
摘要：
Non-alcoholic fatty liver disease (NAFLD) was a world-wide health burden. H3K27 acetylation, long non-coding RNA (lncRNA), and miRNA were all implicated in NAFLD regulation, yet the detailed regulatory mechanism was not well understood. LncRNA NEAT1, miR-212-5p, and GRIA3 expression were detected both in high fatty acid-treated hepatocytes cells and NAFLD patients. Lipid droplets were stained and analyzed by oil red O staining. Expression of fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), and GRIA3 was detected by qRT-PCR and western blot. RNA level of lncRNA NEAT1 and miR-212-5p was analyzed by qRT-PCR. The binding sequences of lncRNA NEAT1/miR-212-5p and miR-212-5p/GRIA3 were predicted bioinformatically and validated through luciferase assay. ChIP was performed to analyze H3K27 acetylation on the promoter of lncRNA NEAT1. LncRNA NEAT1 and GRIA3 was upregulated, while miR-212-5p was downregulated in NAFLD patients. FFA promoted lncRNA NEAT1 and GRIA3 expression while suppressing miR-212-5p and promoted lipid accumulation as indicated by increased oil red O staining and FAS and ACC expression. ChIP indicated enrichment of H3K27 on NEAT1 promoter. Inhibition of H3K27 acetylation suppressed lncRNA NEAT1 level. Luciferase results indicated direct interaction of NEAT1/miR-212-5p (which was confirmed by RIP) and miR-212-5p/GRIA3. LncRNA NEAT1 knockdown upregulated miR-212-5p level and inhibited FFA-induced lipid accumulation while suppressing GRIA3 expression. Such function was antagonized by miR-212-5p inhibition and GRIA3 knockdown counteracted with miR-212-5p inhibition. H3K27 acetylation was enriched within the promoter of lncRNA NEAT1 and promoted lncRNA NEAT1 transcription. LncRNA NEAT1 could then interact with miR-212-5p and suppress its cellular concentration.
