期刊：
Journal of Pharmacy and Pharmaceutical Sciences,2021年24:488-498 ISSN：1482-1826
通讯作者：
Liu, Yunmei;Du, Li
作者机构：
[Liu, Yunmei; Duan, Haiying; Wang, Xiaoying; Zhu, Xuefeng; Li, Dujuan] Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.;[Lu, Yuxin; Zhang, Qinglin; Duan, Haiying; Xiao, Fengjun; Zhu, Xuefeng; Li, Dujuan; Du, Li; Cheng, Xiaochen] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.;[Gao, Peng] Xuzhou Med Univ, Affiliated Hosp 2, Xuzhou, Jiangsu, Peoples R China.;[Hu, Chunsheng] Chongqing Univ Arts & Sci, Natl & Local Joint Engn Res Ctr Targeted & Innova, Coll Pharm, Chongqing, Peoples R China.;[Hu, Chunsheng] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, Chongqing, Peoples R China.
通讯机构：
[Liu, Yunmei] U;[Du, Li] B;Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.;Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.
摘要：
Purpose: Silicosis is a serious occupational disease that is characterized by pulmonary infiltrates and fibrosis and is often refractory to current treatments. New therapeutic strategies for silicosis are needed. Hepatocyte growth factor (HGF) is a latent anti-inflammatory and anti-fibrotic growth factor. Methods: We prepared a polyethyleneimine-polyethylene glycol/pHGF/hyaluronic acid (PEG-PEI/pHGF/HA) nanomaterials loaded with plasmid DNA encoding HGF gene to increase its transfection efficiency. The characterization, including DNA entrapment efficiency, morphology, particle size, and zeta-potential of PEG-PEI/pHGF/HA was studied. And a PEG-PEI/pHGF/HA (N/P=30:1) nanoparticle with low toxicity and high transfection efficiency was used in treatment for silicosis in mice. Results: The results showed that the human HGF expression in the lungs of the mice was increased, and the inflammatory cell infiltration and fibrous collagen deposition was significantly reduced. Conclusion: Therefore, PEG-PEI/pHGF/HA nanoparticle warrant further investigation and may be a potential therapeutic strategy for silicosis.
