A Nanoparticle Delivery of Plasmid Encoding Hepatocyte Growth Factor for Gene Therapy of Silicosis in Mice

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成果类型：

期刊论文

作者：

Duan, Haiying;Gao, Peng;Cheng, Xiaochen;Lu, Yuxin;Hu, Chunsheng;...

通讯作者：

Liu, Yunmei;Du, Li

作者机构：

[Liu, Yunmei; Duan, Haiying; Wang, Xiaoying; Zhu, Xuefeng; Li, Dujuan] Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.

[Lu, Yuxin; Zhang, Qinglin; Duan, Haiying; Xiao, Fengjun; Zhu, Xuefeng; Li, Dujuan; Du, Li; Cheng, Xiaochen] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.

[Gao, Peng] Xuzhou Med Univ, Affiliated Hosp 2, Xuzhou, Jiangsu, Peoples R China.

[Hu, Chunsheng] Chongqing Univ Arts & Sci, Natl & Local Joint Engn Res Ctr Targeted & Innova, Coll Pharm, Chongqing, Peoples R China.

[Hu, Chunsheng] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, Chongqing, Peoples R China.

通讯机构：

[Liu, Yunmei] U

[Du, Li] B

Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.

Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.

语种：

英文

期刊：

Journal of Pharmacy and Pharmaceutical Sciences

ISSN：

1482-1826

年：

2021

卷：

页码：

488-498

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Purpose: Silicosis is a serious occupational disease that is characterized by pulmonary infiltrates and fibrosis and is often refractory to current treatments. New therapeutic strategies for silicosis are needed. Hepatocyte growth factor (HGF) is a latent anti-inflammatory and anti-fibrotic growth factor. Methods: We prepared a polyethyleneimine-polyethylene glycol/pHGF/hyaluronic acid (PEG-PEI/pHGF/HA) nanomaterials loaded with plasmid DNA encoding HGF gene to increase its transfection efficiency. The characterization, including DNA entrapment efficiency, morphology, particle size, and zeta-p...

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A Nanoparticle Delivery of Plasmid Encoding Hepatocyte Growth Factor for Gene Therapy of Silicosis in Mice

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