作者： Tang, Yonghong;Ou, Guifang;Rang, Ouyan;Liu, Xu;Liu, Xiaocheng;...

期刊： Human & Experimental Toxicology,2024年43:9603271241232609 ISSN：0960-3271

通讯作者： Wang, M;Yang, Q

作者机构： [Ou, Guifang; Liu, Xiaocheng; Qin, Xinru; Liu, Xu; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Yang, Qing] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Nucl Ind Hyg Sch, Clin Res Inst,Hengyang Med Sch, Hengyang, Peoples R China.;[Ou, Guifang; Liu, Xiaocheng; Qin, Xinru; Liu, Xu; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Yang, Qing] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang, Peoples R China.;[Qin, Xinru; Liu, Xu] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.;[Li, Guojuan] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Endocrinol Dept, Hengyang, Peoples R China.;[Wang, Mu] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构： [Wang, M ; Yang, Q ] U;Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Nanhua Hosp, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dongfeng Nan Rd 336, Hengyang, Peoples R China.

关键词： 4,4' isopropylidenediphenol;cerebroside;cholesterol;fructose;hexosylceramide;icosanoid;lysophosphatidylcholine;membrane lipid;phosphatidylcholine;phosphatidylethanolamine;phosphatidylinositol;phosphatidylserine;triacylglycerol;unclassified drug;4,4' isopropylidenediphenol;benzhydryl derivative;lipid;phenol derivative;adipose tissue;animal experiment;animal model;animal tissue;Article;centrifugation;controlled study;degree of unsaturation;dose response;electrospray mass spectrometry;fatty acid desaturation;freeze drying;intra-abdominal fat;ion chromatography;lipid analysis;lipid composition;lipid metabolism;lipid remodeling;lipid storage;lipidomics;liquid chromatography-mass spectrometry;long term exposure;male;molecular weight;nonhuman;quality control;quantitative analysis;rat;retention time (chromatography);tandem mass spectrometry;total ion flow chromatogram;triple quadrupole mass spectrometry;ultra performance liquid chromatography;ultrasound;white adipose tissue;adipose tissue;animal;human;lipid metabolism;metabolism;Adipose Tissue;Animals;Benzhydryl Compounds;Fructose;Humans;Lipid Metabolism;Lipidomics;Lipids;Phenols;Rats

摘要： Human & Experimental Toxicology, Volume 43, Issue , January-December 2024. <br/>Adipose tissue is the main organ that stores lipids and it plays important roles in metabolic balance in the body. We recently reported in Human and Experimental Toxicology that the combined exposure to BPA and fructose may interfere with energy metabolism of adipose tissue. However, it is still unclear whether the combined exposure to BPA and fructose has the possibility to induce lipid remodeling in adipose tissue. In the present study, we performed a widely targeted quantitative lipidomic analysis of the adipose tissue of rats after 6 months of BPA and fructose combined exposure. We totally determined 734 lipid molecules in the adipose tissue of rats. Principal component analysis (PCA) showed the group of the combined exposure to higher-dose (25 μg/kg every other day) BPA and fructose can be distinguished from the groups of control, higher-dose BPA exposure and fructose exposure clearly. Partial least squares-discriminant analysis (PLS-DA) and univariate statistical analysis displayed lipids of PC(18:0_ 20:3), TG(8:0_14:0_16:0), TG(12:0_14:0_16:1), TG(10:0_16:0_16:1), TG(12:0_ 14:0_18:1), TG(14:0_ 16:0_16:1), TG(14:0_14:1_16:1), TG(8:0_ 16:1_16:2), TG(14:1_16:1_ 16:1), TG(16:1_18:1_18:1), TG(16:0_16:1_20:4) and TG(15:0_18:1_ 24:1) may contributed the most to the discrimination. These findings indicated that combined exposure to BPA and fructose has the potential to cause lipid remodeling in adipose tissue.

语种： 英文

作者： Tang, Xian;Han, Hai;Li, Le;Wang, Hongqing

期刊： Microchemical Journal,2024年199:109924 ISSN：0026-265X

通讯作者： Tang, X;Li, L

作者机构： [Tang, Xian; Han, Hai] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Li, Le] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;[Wang, Hongqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Wang, Hongqing] Univ South China, Hunan key Lab Design & Applicat Actinide Complexes, Hengyang 421001, Hunan, Peoples R China.

通讯机构： [Tang, X ; Li, L ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

关键词： DNAzymes;Ion -imprinted polymers;2D materials;Probe materials;On -site monitoring

摘要： Uranium, highly chemically toxic and radioactive with a long half-life, poses environmental risks due to activities like uranium mining, refining, and nuclear power plant operations. Detecting uranyl ion in real-time is crucial to assess human health risks and control uranium pollution. Electrochemical sensing offers advantages such as sensitivity, selectivity, simplicity, rapidity, and cost-effectiveness, making it ideal for on-site detection of uranyl ion. This paper summarizes recent research progress in electrochemical detection of uranyl. Various techniques including cyclic voltammetry, differential pulse voltammetry, stripping voltammetry, and electrochemical impedance spectroscopy are discussed along with their respective advantages. Detection methods utilizing electrode-modified functional materials like biomaterials, polymers, and nanomaterials are investigated. Probes like DNAzyme, ion-imprinted polymers, and 2D materials are highlighted for their detection mechanism and effectiveness. Electrochemical sensing with these probes achieves nanomolar-level detection limits (nM) with excellent stability and selectivity, suggesting practical applications. Lastly, predictions are made regarding sensing mechanisms, electrode material selection, and adaptability to field conditions for electrochemical detection of uranyl ion. © 2024 Elsevier B.V.

语种： 英文

作者： Ding, Jianqiang;Yuan, Yali*;Xu, Jinsheng;Deng, Jian;Guo, Jianbo

期刊： JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2009年5(5):521-527 ISSN：1550-7033

通讯作者： Yuan, Yali

作者机构： [Ding, Jianqiang; Guo, Jianbo] Univ S China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;[Yuan, Yali; Deng, Jian] Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Xu, Jinsheng] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China.

通讯机构： [Yuan, Yali] U;Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

关键词： Anatase TiO;Boron ions;Chemical environment;Chemical state;Co-doped;Crystalline structure;Diffuse reflectance spectroscopy;Hydrolyzation-precipitation method;Methyl Orange;Methyl orange degradation;Nano powders;Photo catalytic degradation;Photocatalytic activities;Synergistic effect;TiO;UV-vis-DRS;Visible light;Azo dyes;Boron;Doping (additives);Grain growth;Industrial chemicals;Iodine;Light;Photocatalysts;Photodegradation;Precipitation (chemical);Reconnaissance aircraft;Spectroscopy;Titanium dioxide;X ray diffraction;X ray photoelectron spectroscopy;boron;iodine;methyl orange;tin oxide;titanium dioxide;nanomaterial;titanium;article;chemical environment;crystal structure;diffuse reflectance spectroscopy;hydrolysis;light;light absorption;photocatalysis;photodegradation;precipitation;ultraviolet irradiation;ultraviolet spectroscopy;X ray diffraction;X ray photoelectron spectroscopy;catalysis;chemistry;conformation;crystallization;light;macromolecule;materials testing;methodology;nanomedicine;particle size;photochemistry;powder;radiation dose;radiation exposure;surface property;ultrastructure;Boron;Catalysis;Crystallization;Iodine;Light;Macromolecular Substances;Materials Testing;Molecular Conformation;Nanomedicine;Nanostructures;Particle Size;Photochemistry;Powders;Radiation Dosage;Surface Properties;Titanium

摘要： An iodine and boron co-doped TiO2 photocatalyst was prepared by the hydrolyzation-precipitation method. X-ray diffraction (XRD), ultraviolet-visible diffuse reflectance spectroscopy (UV-Vis DRS), and X-ray photoelectron spectroscopy (XPS) were applied to characterize the crystalline structure, light absorbing ability, and the chemical state of iodine and boron in the photocatalysts. The results of photocatalytic degradation of methyl orange demonstrated that the I-B-TiO2 catalyst prepared at 400 °C for 3 h exhibited the highest photocatalytic activity with a methyl orange degradation ratio of 61% under visible-light (λ ≤ 420 nm) irradiation for 120 min. The characterization results revealed that I-B-TiO2 is in conformity with the anatase TiO2 and that the doping of iodine and boron ions could efficiently inhibit the grain growth. Doped iodine was present in the multivalent forms of I7+, I- and I5+. Doped boron was present as B3+ in an as-prepared sample, forming a possible chemical environment such as B-O-Ti. Overall, the doping of I and B enhanced the ability of TiO2 to absorb visible-light, and it was observed that the photocatalytic activity of I-B-TiO2 was enhanced by the synergistic effect of I and B. Copyright © 2009 American Scientific Publishers All rights reserved.

语种： 英文