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Widely targeted quantitative lipidomics reveal lipid remodeling in adipose tissue after long term of the combined exposure to bisphenol A and fructose

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成果类型:
期刊论文
作者:
Tang, Yonghong;Ou, Guifang;Rang, Ouyan;Liu, Xu;Liu, Xiaocheng;...
通讯作者:
Wang, M;Yang, Q
作者机构:
[Ou, Guifang; Liu, Xiaocheng; Qin, Xinru; Liu, Xu; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Yang, Qing] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Nucl Ind Hyg Sch, Clin Res Inst,Hengyang Med Sch, Hengyang, Peoples R China.
[Ou, Guifang; Liu, Xiaocheng; Qin, Xinru; Liu, Xu; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Yang, Qing] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang, Peoples R China.
[Qin, Xinru; Liu, Xu] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.
[Li, Guojuan] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Endocrinol Dept, Hengyang, Peoples R China.
[Wang, Mu] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wang, M ; Yang, Q ] U
Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Affiliated Nanhua Hosp, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dongfeng Nan Rd 336, Hengyang, Peoples R China.
语种:
英文
关键词:
4,4' isopropylidenediphenol;cerebroside;cholesterol;fructose;hexosylceramide;icosanoid;lysophosphatidylcholine;membrane lipid;phosphatidylcholine;phosphatidylethanolamine;phosphatidylinositol;phosphatidylserine;triacylglycerol;unclassified drug;4,4' isopropylidenediphenol;benzhydryl derivative;lipid;phenol derivative;adipose tissue;animal experiment;animal model;animal tissue;Article;centrifugation;controlled study;degree of unsaturation;dose response;electrospray mass spectrometry;fatty acid desaturation;freeze drying;intra-abdominal fat;ion chromatography;lipid analysis;lipid composition;lipid metabolism;lipid remodeling;lipid storage;lipidomics;liquid chromatography-mass spectrometry;long term exposure;male;molecular weight;nonhuman;quality control;quantitative analysis;rat;retention time (chromatography);tandem mass spectrometry;total ion flow chromatogram;triple quadrupole mass spectrometry;ultra performance liquid chromatography;ultrasound;white adipose tissue;adipose tissue;animal;human;lipid metabolism;metabolism;Adipose Tissue;Animals;Benzhydryl Compounds;Fructose;Humans;Lipid Metabolism;Lipidomics;Lipids;Phenols;Rats
期刊:
Human & Experimental Toxicology
ISSN:
0960-3271
年:
2024
卷:
43
页码:
9603271241232609
基金类别:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Key Project of Hunan provincial science and technology innovation (No. 2020sk1012); Natural Science Foundation of Hunan Province (No. 2022JJ30547); the excellent youthful project Scientific research of Hunan Provincial Department of Education: (No. 20B491); "4310" cultivation program of clinical medicine research of Hengyang Medical School, University of South China [HengYiFa (2021) No. 1].
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Human & Experimental Toxicology, Volume 43, Issue , January-December 2024. Adipose tissue is the main organ that stores lipids and it plays important roles in metabolic balance in the body. We recently reported in Human and Experimental Toxicology that the combined exposure to BPA and fructose may interfere with energy metabolism of adipose tissue. However, it is still unclear whether the combined exposure to BPA and fructose has the possibility to induce lipid remodeling in adipose tissue. In the present study, we performed a widely targeted q...

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