作者机构：
[Ma, Q.; Liu, H.; Liu, Y.; Guo, Z.] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Guo, Z.] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
通讯机构：
[Z. Guo] S;School of Nursing, University of South China, Hengyang, China<&wdkj&>Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China
摘要：
Objective: This study aimed to systematically clarify attitudes and influencing factors of the public toward COVID-19 vaccination for children or adolescents. Study design: This was a scoping review. Methods: This scoping review screened, included, sorted, and analyzed relevant studies on COVID-19 vaccination for children or adolescents before December 31, 2021, in databases, including PubMed, Elsevier, Web of Science, Cochrane Library, and Wiley. Results: A total of 34 studies were included. The results showed that the public's acceptance rate toward COVID-19 vaccination for children or adolescents ranged from 4.9% (southeast Nigerian mothers) to 91% (Brazilian parents). Parents' or adolescents' age, gender, education level, and cognition and behavior characteristics for the vaccines were the central factors affecting vaccination. The vaccine's safety, effectiveness, and potential side-effects were the main reasons affecting vaccination. Conclusions: Realizing current public attitudes of COVID-19 vaccination for adolescents or children can effectively develop intervention measures and control the pandemic as soon as possible through herd immunity. (c) 2022 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
期刊：
Western Journal of Nursing Research,2022年44(9):874-885 ISSN：0193-9459
通讯作者：
Pingping He
作者机构：
[Wen, Min; He, Pingping; Shen, Qianqian] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Liang, Yaqin] Shaoguan Univ, Med Coll, Shaoguan, Peoples R China.;[Shen, Qianqian] Jiaxing Univ, Affiliated Hosp 2, Hosp Jiaxing 2, Jiaxing, Zhejiang, Peoples R China.;[Yu, Juping] Univ South Wales, Fac Life Sci & Educ, Pontypridd, M Glam, Wales.;[He, Pingping] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Nursing, Inst Cardiovasc Dis,Key Lab Ateriosclerol Hunan P, Hengyang, Peoples R China.
通讯机构：
[Pingping He] S;School of Nursing, University of South China, Hengyang, P.R. China<&wdkj&>School of Nursing, Institute of Cardiovascular Disease, Key Laboratory for Ateriosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, P.R. China
摘要：
This cluster randomized controlled trial aimed to investigate the effects of an intervention to teach resourcefulness on depression and coping style of patients with coronary heart disease (CHD). A convenience sample of 72 patients in community settings took part. Participants in the intervention group (n = 36) received an 8-week intervention based on the concept of resourcefulness, plus routine health education. Participants in the control group (n = 36) received routine health education only. After the intervention, participants in the intervention group had significantly higher scores on resourcefulness and coping styles, and lower scores on depression than those in the control group (both ps < .001). The findings suggest that a well-developed intervention to teach resourcefulness could help patients with CHD to be more resourceful, improve their level of depression, and choose more effective strategies to cope with stress.
作者机构：
[Yue, Qian-qian; Tang, Tian; Zeng, Ying; Wang, Ying-xin; Hu, Li-feng; Huang, Ruo-lin; Xiao, Qiao; Zou, Jin-yu; Liu, Qi; Sun, Ying-xue] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.;[Liu, Qi] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Canc Res Inst, Hengyang Med Sch, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Hunan, Peoples R China.;[Zeng, Xi] Univ South China, Hengyang Med Sch, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.
通讯机构：
[Zeng, Ying] H;Hengyang Medical School, School of Nursing, University of South China, Hengyang, Hunan, China
关键词：
gastrointestinal tumours;infection control;public health
摘要：
<jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the general population’s awareness of and attitudes toward<jats:italic>Helicobacter pylori</jats:italic>(HP) screening and health behaviours.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Cross-sectional study.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Hengyang, Hunan Province, China.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Using stratified cluster random sampling, a pretested structured questionnaire was used to interview members of the general population aged ≥18 years.</jats:p></jats:sec><jats:sec><jats:title>Primary and secondary outcome measures</jats:title><jats:p>Knowledge of and attitudes toward HP screening and associated health behaviours, sociodemographic factors associated with HP knowledge, and screening behaviours.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>This study featured 1042 participants. The average knowledge score was 11 (Q<jats:sub>L</jats:sub>=4, Q<jats:sub>U</jats:sub>=20, range 0–29). Approximately 68.9% of the participants said they had heard of HP, but 67.5% had never had an HP test. The most common reasons for not undergoing screening were ‘no symptoms’ (55.7%) and ‘lack of knowledge regarding the benefits of the test’ (21.1%). Independent factors related to knowledge included age, education level, occupation, HP infection, frequency of drinking unboiled water (p<0.05). Factors independently associated with screening behaviour included occupation, average monthly income, presence/absence of indigestion, stomach discomfort or pain, and/or stomach disease and knowledge score (p<0.05). Overall, 941 (90.3%) participants never used anti-HP toothpaste, and 442 (40.5%) never used serving spoons or chopsticks. The risk factors for HP infection included eating out and eating in groups (p<0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In China, the general population has poor knowledge of HP, but most people have a positive attitude towards HP screening. Being asymptomatic and lacking knowledge about testing were the main reasons for reluctance to be screened. These results highlight the urgent need for educational activities to raise awareness, enhance screening rates for HP, and encourage people to adopt a healthy lifestyle.</jats:p></jats:sec>
期刊：
Reviews in the Neurosciences,2020年32(1):79-91 ISSN：0334-1763
通讯作者：
Li, Meixiang;Tan, Sijie
作者机构：
[Tan, Sijie; Li, Meixiang; Tan, SJ; Huang, Zeyi; Wu, Daichao] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Qu, Xilin] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Grade Clin Med 2017, Hengyang 421001, Hunan, Peoples R China.;[Zou, Ju] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Parasitol,Hunan Prov Key Lab Special Pathoge, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, MX; Tan, SJ] U;Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
addiction;BDNF;nAChRs;nicotine;TrkB
摘要：
Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine dependence. Nicotine addiction is deemed to be a chronic mental disorder. Although it is well known that nicotine binds to the nicotinic acetylcholine receptors (nAChRs) and activates the mesolimbic dopaminergic system (MDS) to generate the pleasant and rewarding effects, the molecular mechanisms of nicotine addiction are not fully understood. Brain-derived neurotrophic factor (BDNF) is the most prevalent growth factor in the brain, which regulates neuron survival, differentiation, and synaptic plasticity, mainly through binding to the high affinity receptor tyrosine kinase receptor B (TrkB). BDNF gene polymorphisms are associated with nicotine dependence and blood BDNF levels are altered in smokers. In this review, we discussed the effects of nicotine on BDNF expression in the brain and summarized the underlying signaling pathways, which further indicated BDNF as a key regulator in nicotine dependence. Further studies that aim to understand the neurobiological mechanism of BDNF in nicotine addcition would provide a valuable reference for quitting smoking and developing the treatment of other addictive substances.
摘要：
<jats:sec><jats:title>Objectives</jats:title><jats:p>This study aimed to assess the knowledge of risk factors and warning symptoms and attitude towards gastric cancer screening among the general population in China.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Hunan province, China</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Individuals aged older than 18 years were recruited using a cluster sampling method.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>A cross-sectional study, and a pretested structured questionnaire was used to assess participants’ awareness of gastric cancer.</jats:p></jats:sec><jats:sec><jats:title>Primary and secondary outcome measures</jats:title><jats:p>Knowledge level of risk factors and warning symptoms of gastric cancer, gastric cancer screening attitude, sociodemographic factors associated with gastric cancer knowledge and screening behaviour.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>This study comprised 1200 participants with a mean age of 40.31 (SD 16.73) years, of whom 622 (51.8%) were women. The mean score for gastric cancer knowledge was 8.85/22 (SD 6.48). There were 47.0% of the participants who had a low knowledge level about the risk factors and warning symptoms of gastric cancer. In total, 83.8% believed screening is helpful for early detection of gastric cancer, and 15.2% had undergone gastric cancer screening. The most common reason for not undergoing screening was having ‘no symptoms’ (63.0%), followed by ‘fear of undergoing gastroscopy’ (38.1%). Independent factors related to lower knowledge levels included male sex, living in rural areas, lower educational level, working as a farmer and without a family history of gastric cancer (p<0.05). Factors independently associated with screening behaviour included white-collar employment, higher income and having upper gastrointestinal tract diseases (p<0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In China, people have poor knowledge about risk factors and warning symptoms of gastric cancer, but a majority have a positive attitude towards the benefits of gastric cancer screening. Being asymptomatic and having a fear of gastroscopy were the main self-reported reasons for not undergoing screening. These results highlight the urgent need for educational campaigns to improve gastric cancer awareness.</jats:p></jats:sec>
作者机构：
[Chen, Wen-Lin; Xie, Bin; Niu, Ying-Ying; Tang, Xiao-Qing; Xu, Kang-Li; Zou, Wei; Hu, Bi; Zhang, Chong; Zhang, Ping] Univ South China, Coll Med, Inst Cognit & Nervous Syst Dis, Hengyang 421001, Hunan, Peoples R China.;[Tian, Ying] Univ South China, Coll Med, Dept Biochem, Hengyang 421001, Hunan, Peoples R China.;[Chen, Wen-Lin; Xie, Bin; Niu, Ying-Ying; Xu, Kang-Li; Zhang, Chong] Univ South China, Coll Med, Hengyang 421001, Hunan, Peoples R China.;[Tang, Xiao-Qing] Univ South China, Inst Cognit & Nervous Syst Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tang, Xiao-Qing] U;Univ South China, Inst Cognit & Nervous Syst Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
anxiety, depression, elevated plus maze, forced swimming test, hydrogen sulfide, mouse, rat, tail suspension test
摘要：
Depression is a common and debilitating mental illness and is often comorbid with anxiety disorders. Altered synaptic plasticity is considered to be an important mechanism underlying antidepressant drug action. It has been reported that hydrogen sulfide (H2S), the third gaseous transmitter, facilitates the induction of hippocampal long-term potentiation and augments synaptic neurotransmission, involved in the regulation of synaptic plasticity. The aim of this study was to clarify the antidepressant-like and anxiolytic-like effects of H2S. H2S (NaHS, 1.68 or 5.6 mg/kg, intraperitoneally, for 7 days) exerts a specific antidepressant-like effect in the forced swimming test of mice and rats and the tail suspension test of mice, and reduces the anxiety-like behaviors of both mice and rats in the elevated plus-maze test. These results reveal a unique antagonistic action of H2S in depressive-like and anxiety-like behaviors and suggest that elevating H2S signaling in the brain may represent a novel approach for the treatment of depressive and anxiety disorders.
