BDNF and nicotine dependence: associations and potential mechanisms

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Zeyi;Wu, Daichao;Qu, Xilin;Li, Meixiang*;Zou, Ju;...

通讯作者：

Li, Meixiang;Tan, Sijie

作者机构：

[Tan, Sijie; Li, Meixiang; Tan, SJ; Huang, Zeyi; Wu, Daichao] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Qu, Xilin] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Grade Clin Med 2017, Hengyang 421001, Hunan, Peoples R China.

[Zou, Ju] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Parasitol,Hunan Prov Key Lab Special Pathoge, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, MX; Tan, SJ] U

Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

addiction;BDNF;nAChRs;nicotine;TrkB

期刊：

Reviews in the Neurosciences

ISSN：

0334-1763

年：

2020

卷：

期：

页码：

79-91

DOI：

10.1515/revneuro-2020-0044

基金类别：

Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ40250]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 81301144]; Research Learning and Innovative Experiment Project for University Students of University of South China [2018XJX377]; Outstanding Youth Project of Hunan Education Department [18B262, 19B475]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine dependence. Nicotine addiction is deemed to be a chronic mental disorder. Although it is well known that nicotine binds to the nicotinic acetylcholine receptors (nAChRs) and activates the mesolimbic dopaminergic system (MDS) to generate the pleasant and rewarding effects, the molecular mechanisms of nicotine addiction are not fully understood. Brain-deri...

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BDNF and nicotine dependence: associations and potential mechanisms

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