期刊：
Reviews in the Neurosciences,2020年32(1):79-91 ISSN：0334-1763
通讯作者：
Li, Meixiang;Tan, Sijie
作者机构：
[Tan, Sijie; Li, Meixiang; Tan, SJ; Huang, Zeyi; Wu, Daichao] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Qu, Xilin] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Grade Clin Med 2017, Hengyang 421001, Hunan, Peoples R China.;[Zou, Ju] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Parasitol,Hunan Prov Key Lab Special Pathoge, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, MX; Tan, SJ] U;Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Histol & Embryol,Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
addiction;BDNF;nAChRs;nicotine;TrkB
摘要：
Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine dependence. Nicotine addiction is deemed to be a chronic mental disorder. Although it is well known that nicotine binds to the nicotinic acetylcholine receptors (nAChRs) and activates the mesolimbic dopaminergic system (MDS) to generate the pleasant and rewarding effects, the molecular mechanisms of nicotine addiction are not fully understood. Brain-derived neurotrophic factor (BDNF) is the most prevalent growth factor in the brain, which regulates neuron survival, differentiation, and synaptic plasticity, mainly through binding to the high affinity receptor tyrosine kinase receptor B (TrkB). BDNF gene polymorphisms are associated with nicotine dependence and blood BDNF levels are altered in smokers. In this review, we discussed the effects of nicotine on BDNF expression in the brain and summarized the underlying signaling pathways, which further indicated BDNF as a key regulator in nicotine dependence. Further studies that aim to understand the neurobiological mechanism of BDNF in nicotine addcition would provide a valuable reference for quitting smoking and developing the treatment of other addictive substances.
期刊：
Nursing & Health Sciences,2020年22(4):892-902 ISSN：1441-0745
通讯作者：
Zeng, Ying
作者机构：
[Huang, Yanjin; He, Guoping; Liu, Juanjuan; Zeng, Ying; Wang, Wen; Liu, Qi] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Liu, Juanjuan] Hunan Univ Med, Sch Rehabil Med & Hlth, Huaihua, Peoples R China.;[Zeng, Ying] Univ South China, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
通讯机构：
[Zeng, Ying] U;Univ South China, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
关键词：
care preparedness;cross-sectional study;family caregiver;knowledge;stroke;uncertainty
摘要：
Family caregivers play an important role in the rehabilitation of stroke survivors. The aim of this study was to describe preparedness, uncertainty and knowledge regarding stroke in family caregivers of people who have undergone strokes, and to investigate factors influencing preparedness. A total of 306 caregivers completed the questionnaires including the Caregiver Preparedness Scale, the Mishel Uncertainty in Illness Scale and Knowledge of Stroke. The result showed that the mean score of the family caregivers preparedness was 14.42, the mean score of disease uncertainty was 75.62, and the mean score of stroke knowledge was 10.41. Caregiver preparedness was negatively correlated with disease uncertainty and positively correlated with knowledge. Multivariate stepwise regression analysis showed that educational background, profession, caregiving experience and uncertainty degree of the family caregivers, gender and age of stroke survivor could predict 45.90% of the total variation in preparedness. The findings suggest that demographic characteristics of stroke survivor and family caregiver as well as caregivers' disease uncertainty enable predict the level of caregiver preparedness. Medical professionals should pay attention to providing personalized and targeted approaches to maximize caregivers' preparedness. This article is protected by copyright. All rights reserved.
摘要：
Major depression disorder is one of the most common psychiatric disorders that greatly threaten the mental health of a large population worldwide. Previous studies have shown that endoplasmic reticulum (ER) stress plays an important role in the pathophysiology of depression, and current research suggests that brain-derived neurotrophic factor precursor (proBDNF) is involved in the development of depression. However, the relationship between ER and proBDNF in the pathophysiology of depression is not well elucidated. Here, we treated primary hippocampal neurons of mice with corticosterone (CORT) and evaluated the relationship between proBDNF and ERS. Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN. Anti-proBDNF neutralization and ISRIB (an inhibitor of the ERS) treatment,
respective
ly, protected neuronal viabilities and increased the expression of synaptic-related proteins in corticosterone-exposed neurons. ISRIB treatment reduced the expression of proBDNF and FSTL4, whereas anti-proBDNF treatment did not affect ERS markers (Grp78, p-PERK, ATF4) expression. Our study presented evidence that CORT-induced ERS negatively regulated the neuronal viability and the level of synaptic-related protein of primary neurons via the proBDNF/FSTL4 pathway.
期刊：
International Journal of Clinical and Experimental Medicine,2020年13(5):2993-3001 ISSN：1940-5901
通讯作者：
Wang, Zhen
作者机构：
[Ying, Jianhua; Wang, Zhen] South China Univ, South China Hosp, Outpatient Dept, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.;[Wu, Caiyun] South China Univ, South China Hosp, Anesthet Operat Dept, Hengyang, Hunan, Peoples R China.;[He, Jun] Univ South China, Nanhua Affiliated Hosp, Dept Clin Lab, Hengyang, Hunan, Peoples R China.
通讯机构：
[Wang, Zhen] S;South China Univ, South China Hosp, Outpatient Dept, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.
摘要：
Objective: To explore the effect of personalized nursing on the prevention of infections and the safety of patients with intravenous indwelling needles. Methods: From June 2016 to January 2018, 112 patients who underwent venous indwelling needle puncture in our hospital were selected as the study subjects. Among them, 60 cases who were administered intravenous indwelling needles during their treatment were selected as the control group (CG), and the remaining 52 patients who were treated with personalized nursing on the basis of routine nursing were selected as the research group (RG). The puncture success rate, indwelling time, adverse reactions, catheter removal rate and blocking rate, pain, compliance, and nursing satisfaction were compared between the two groups. Results: Compared with the CG, the RG presented a markedly higher puncture success rate (P<0.05), a significantly longer intravenous indwelling time (P<0.05), a notably lower incidence of total adverse reactions (P<0.05), and significantly lower rates of catheter removal and blocking (P<0.05). The VAS scores in the RG were significantly lower than they were in the CG (P<0.05). The infusion compliance in the RG was significantly higher than it was in the CG (P<0.05), as was the case with the nursing satisfaction (P<0.05). Conclusion: Personalized nursing can reduce the indwelling needle infection rate, improve the safety of infusions, and improve the quality of medical treatment.
作者：
Gao, Shan;Ling, Shuang*;Liu, Xiaozhou;Dou, Xin;Wu, Rong
期刊：
Journal of Cleaner Production,2020年263:121311 ISSN：0959-6526
通讯作者：
Ling, Shuang
作者机构：
[Gao, Shan; Wu, Rong; Liu, Xiaozhou; Dou, Xin; Ling, Shuang] Cent South Univ, Sch Publ Adm, Changsha 410083, Hunan, Peoples R China.;[Gao, Shan] Univ South China, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Ling, Shuang] C;Cent South Univ, Sch Publ Adm, Changsha 410083, Hunan, Peoples R China.
关键词：
Information disclosure;Environmental project;Local authorities;Tripartite evolutionary game
摘要：
Both the bottom-up public protest and the up-down superior intervention are the crucial factors of influencing government's action in crisis situation, but few researches have provided a synthetic framework to understand local officials' information openness in China's environmental project construction. In this article, we develop a dual-pressure model to systematically investigate how local governments response the public's information disclosure appeals in the progress of environmental project construction. To achieve this goal, a tripartite evolutionary game model among the central government, local authorities and local residents was conducted to explain local authorities' disclosure action. Particular attention was given to examine how both the bottom-up social protest and the top-down superior intervention, and their relation between them influence local government's information openness, and also analyze the collective strategies of promoting local governments and their officials to take full disclosure action in the progress of environmental project construction. The findings indicated that local governments and their officials' disclosure strategies are sensitive to the top-down superior intervention, as well as the bottom-up public protest in the progress of environmental project construction, but both of them have different role in influencing local officials to take full disclosure measures. Of which, the bottom-up public protest, though still with a limited scope, can help focus the central government's attention on local officials' limited disclosure, and thus triggering the superior intervention system, and the up-down superior intervention aims to response to local residents' protest to local officials' limited disclosure. The benign interaction between the central government and the public can help break the monopolization of risk information from local bureaucracy, and thus improving local government's disclosure performance. (C) 2020 Elsevier Ltd. All rights reserved.
摘要：
Mounting clinical studies have reported patients with schizophrenia are at high risk of developing sexual dysfunction (SD), but a directly calculated prevalence of SD is currently lacking.
To further quantify the association between schizophrenia and SD.
MEDLINE (PubMed), Embase (OVID), the Cochrane Library databases, and the PsycINFO were systematically searched for eligible studies reporting the sexual functioning in patients with schizophrenia. This meta-analysis has been registered on PROSPERO (ID: CRD42019121720, http://www.crd.york.ac.uk/PROSPERO ).
The relationship between schizophrenia and SD was detected by calculating the relative risk (RR) with a 95% confidence interval (CI). The GRADE-profiler was employed to rank the quality of the evidence.
10 observational studies (3 case-control studies and 7 cross-sectional studies) were finally included, enrolling a total of 3,570 participants (mean age 28.6–46.2 years), of whom 1,161 had schizophrenia and the remainders were the healthy control subjects. Synthetic results indicated that schizophrenia was significantly associated with an increased risk of SD regardless of gender (3 studies reporting both sexes: RR = 2.24, 95%CI: 1.66–3.03, P < .001, heterogeneity: I2 = 0.0%, P = .431; 7 studies reporting men: RR = 2.63, 95%CI: 1.68–4.13, P < .001, heterogeneity: I2 = 82.7%, P < .001; 5 studies reporting women: RR = 2.07, 95%CI: 1.46–2.94, P < .001; heterogeneity: I2 = 79.7%, P = .001). In accordance with the GRADE-profiler, the quality of the evidence of primary outcomes was LOW, MODERATE, and LOW in studies including both sexes, men, and women, respectively.
Our findings confirmed the potential link between schizophrenia and SD. Clinicians should routinely assess the sexual functioning for those patients with schizophrenia and further recommend the preferred antipsychotics for them.
This is the first meta-analysis investigating the association between schizophrenia and the risks of SD in both sexes. Nonetheless, substantial heterogeneities were identified across the selected studies.
Robust data from this meta-analysis showed increased rates of SD in patients with schizophrenia compared with the general populations. Therefore, more specific psychological and pharmaceutical interventions are needed to help patients with schizophrenia gain a better sexual life.
Zhao S, Wang X, Qiang X, et al. Is There an Association Between Schizophrenia and Sexual Dysfunction in Both Sexes? A Systematic Review and Meta-Analysis. J Sex Med 2020;17:1476–1488.
期刊：
JOURNAL OF MEDICAL INTERNET RESEARCH,2020年22(8):e19995- ISSN：1438-8871
通讯作者：
Tang, Zhihan
作者机构：
[Niu, Zhaomeng] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA.;[Wang, Tingting] Sun Yat Sen Univ, Guangzhou, Peoples R China.;[Mei, Jing; Hu, Pengwei] IBM Res, Beijing, Peoples R China.;[Tang, Zhihan] Univ South China, Hengyang Med Coll, 28 West Changsheng Rd, Hengyang 421001, Peoples R China.
通讯机构：
[Tang, Zhihan] U;Univ South China, Hengyang Med Coll, 28 West Changsheng Rd, Hengyang 421001, Peoples R China.
关键词：
COVID-19;China;preventive health behaviors;intervening health behaviors;psychosocial;health literacy;behavior;prevention;cross-sectional
摘要：
Background: Since January 2020, the coronavirus disease (COVID-19) swept over China and then the world, causing a global public health crisis. People's adoption of preventive and intervening behaviors is critical in curbing the spread of the virus. Objective: The aim of this study is to evaluate Chinese people's adoption of health behaviors in responding to COVID-19 and to identify key determinants for their engagement. Methods: An anonymous online questionnaire was distributed in early February 2020 among Mainland Chinese (18 years or older) to examine their engagement in preventive behaviors (eg, frequent handwashing, wearing masks, staying at home) and intervening behaviors (eg, advising family to wash hands frequently), and to explore potential determinants for their adoption of these health behaviors. Results: Out of 2949 participants, 55.3% (n=1629) reported frequent engagement in preventive health behaviors, and over 84% (n=2493) performed at least one intervening health behavior. Greater engagement in preventive behaviors was found among participants who received higher education, were married, reported fewer barriers and greater benefits of engagement, reported greater self-efficacy and emotional support, had greater patient-centered communication before, had a greater media literacy level, and had greater new media and traditional media use for COVID-19 news. Greater engagement in intervening behaviors was observed among participants who were married, had lower income, reported greater benefits of health behaviors, had greater patient-centered communication before, had a lower media literacy level, and had a greater new media and traditional media use for COVID-19 news. Conclusions: Participants' engagement in coronavirus-related preventive and intervening behaviors was overall high, and the associations varied across demographic and psychosocial variables. Hence, customized health interventions that address the determinants for health behaviors are needed to improve people's adherence to coronavirus-related behavior guidelines.
摘要：
Background: Percutaneous injuries and blood-borne-related infections pose occupational hazards to healthcare professionals. However, the prevalence and associated factors for these hazards among midwives in Hunan Province, China are poorly documented. Methods: A cross-sectional study was conducted among a sample of 1,282 eligible midwives in the cities of Yongzhou, Chenzhou, Hengyang, and Changsha in Hunan Province, China, from January 2017 to July 2017. The association of selected independent variables with percutaneous injuries was investigated using binary logistic regression. Results: 992 participants responded (77.3%), and within the previous 12 months, 15.7% experienced percutaneous injuries. In multivariate analysis, hospital size, age, length of employment as a midwife, weekly working hours, and three aspects of Hospital Safety Climate Scale were associated with percutaneous injuries. The risk of percutaneous injuries among the midwives working in hospitals with ≤399 beds was higher than that among those working in hospitals with ≥400 beds by nearly 3 times. Furthermore, the percutaneous injury prevalence of midwives decreased as age increased. Moreover, the probability of percutaneous injuries among the midwives with weekly working hours of >40 was 4.35 times higher compared with that among midwives with weekly working hours of ≤40. Conclusion/Application to practice: The prevalence of percutaneous injuries among midwives in the study hospitals was substantial. Our results further proved that risk mitigation strategies tailored to midwives are needed to reduce this risk. These strategies include ensuring a positive organizational climate, providing highly safe devices, and reducing the workload.
期刊：
BMC PUBLIC HEALTH,2020年20(1):1-8 ISSN：1471-2458
通讯作者：
Luo, Yang
作者机构：
[Wang, Ting; Chen, Mingzhu; Luo, Yang; Zhou, Yanhui; Fu, Jingxia] Cent South Univ, Xiangya Nursing Sch, 172 Tongzipo Rd Yuelu Dist, Changsha 410013, Hunan, Peoples R China.;[Zhou, Yanhui] Univ South China, Affiliated Hosp 1, 69 Chuanshan Rd Shigu Dist, Hengyang 421001, Hunan, Peoples R China.;[Cui, Yanhui] Cent South Univ, Dept Anat & Neurobiol, Sch Basic Med Sci, 172 Tongzipo Rd Yuelu Dist, Changsha 410013, Hunan, Peoples R China.
通讯机构：
[Luo, Yang] C;Cent South Univ, Xiangya Nursing Sch, 172 Tongzipo Rd Yuelu Dist, Changsha 410013, Hunan, Peoples R China.
关键词：
Fertility knowledge;Fertility intention;Childbearing;College students
摘要：
Fertility knowledge is vital to the fertility health of young people and greatly impacts their fertility choices. Delayed childbearing has been increasing in high-income countries, accompanied by the risk of involuntary childlessness or having fewer children than desired. The aim of this study was to investigate knowledge about fertility issues, the related influencing factors, the method of acquiring fertility knowledge, and the relationship between fertility knowledge and fertility intentions among college students. An online cross-sectional survey of Chinese college students was conducted in Hunan Province from March to April 2018. A total of 867 college students from three comprehensive universities responded to a poster invitation utilizing the Chinese version of the Cardiff Fertility Knowledge Scale (CFKS-C). Data were explored and analysed by SPSS (version 22.0) software. Descriptive statistics, chi-squared tests, T-tests, and Pearson’s correlations were used for the measurements. The average percent-correct score on the CFKS-C was 49.9% (SD = 20.8), with greater knowledge significantly related to living in a city district, being not single status, majoring in medicine, being in year 4 or above of study, and intention to have children (all p<0.05). A total of 81.9% of the participants reported that they would like to have children, the average score of the importance of childbearing was 6.3 (SD = 2.7), and the female score was lower than the male score (p = 0.001). A small positive relationship was observed between the CFKS-C and the importance of childbearing (r = 0.074, p = 0.035). Respondents indicated that they gained most of their knowledge from the media and internet (41.4%) and from schools (38.2%). Yong people in college have a modest level of fertility knowledge, a relatively low intention to have a child, and deficiencies in fertility health education. There is a need to improve the accessibility of fertility health services by developing a scientific and reliable fertility health promotion strategy.
摘要：
A set of dynamic evaluation systems based on data envelopment analysis (DEA), Analytic Hierarchy Process (AHP) and Preference Ranking Organization Method for Enrichment Evaluation II has been constructed to determine the financial performance of Chinese nuclear power-related enterprises; the evaluation indicators reflect not only current development but also future development. (1) A comparison of the competitiveness of nine companies is conducted showing that Everbright Jiabao Co. Ltd. has the strongest competitiveness, the relative competitiveness of Dongfang Electric Corporation has declined year by year, and the competitiveness of Atlantic has increased year by year. (2) According to the analysis of the overall sustainable development capability indicated by financial performance, the financial performance of DUNAN Environment and Everbright Jiabao Co. Ltd. is relatively better than that of the other companies, and that of Atlantic is the worst. (3) According to the analysis of the sustainable development capability indicated by investment efficiency and development performance, during the 10-year development period, the investment efficiency and development performance of Dongfang Electric Corporation, DUNAN Environment, Wintime Energy Co. Ltd. and Everbright Jiabao Co. Ltd. increased, while those of Shanghai Electric and Hubei Energy Group Co. Ltd. declined. In the 10-year period, the other three companies, Boasteel Group, Atlantic, and HBIS Group Co. Ltd., developed unevenly. In addition, the investment efficiency and development performance of the nine companies are unbalanced in the two short-term development stages from 2007 to 2011 and from 2011 to 2016.
作者：
Chen, Xianglong;Ouyang, Chunping*;Liu, Yongbin;Bu, Yi
期刊：
International Journal of Environmental Research and Public Health,2020年17(8) ISSN：1661-7827
通讯作者：
Ouyang, Chunping
作者机构：
[Ouyang, Chunping; Chen, Xianglong; Liu, Yongbin] Univ South China, Sch Comp, Hengyang 421001, Peoples R China.;[Bu, Yi] Indiana Univ, Luddy Sch Informat Comp & Engn, Ctr Complex Networks & Syst Res, Bloomington, IN 47408 USA.
通讯机构：
[Ouyang, Chunping] U;Univ South China, Sch Comp, Hengyang 421001, Peoples R China.
关键词：
Bi-LSTM-CRF;domain dictionary;electronic medical records;entity recognition;rules
摘要：
Electronic medical records are an integral part of medical texts. Entity recognition of electronic medical records has triggered many studies that propose many entity extraction methods. In this paper, an entity extraction model is proposed to extract entities from Chinese Electronic Medical Records (CEMR). In the input layer of the model, we use word embedding and dictionary features embedding as input vectors, where word embedding consists of a character representation and a word representation. Then, the input vectors are fed to the bidirectional long short-term memory to capture contextual features. Finally, a conditional random field is employed to capture dependencies between neighboring tags. We performed experiments on body classification task, and the F1 values reached 90.65%. We also performed experiments on anatomic region recognition task, and the F1 values reached 93.89%. On both tasks, our model had higher performance than state-of-the-art models, such as Bi-LSTM-CRF, Bi-LSTM-Attention, and Vote. Through experiments, our model has a good effect when dealing with small frequency entities and unknown entities; with a small training dataset, our method showed 2-4% improvement on F1 value compared to the basic Bi-LSTM-CRF models. Additionally, on anatomic region recognition task, besides using our proposed entity extraction model, 12 rules we designed and domain dictionary were adopted. Then, in this task, the weighted F1 value of the three specific entities extraction reached 84.36%.
关键词：
job burnout;job satisfaction;mental hospital staff;relationship;structural equation model
摘要：
OBJECTIVES: To understand the relationship between job burnout and job satisfaction for medical workers and analyse the influencing factors. METHODS: We used two scales to examine medical workers in Hengyang mental hospitals. Multivariate logistic regression and structural equation model were used to evaluate the relevant factors of job satisfaction, and the relationship between job satisfaction and job burnout. RESULTS: The total job satisfaction was at the moderate level. For job burnout was in the middle burnout level. Job satisfaction can have a negative prediction function for job burnout (direct effect -0.684). The relevant factors of job burnout and job satisfaction was as follows: nature of the work, pay, benefits and communication impacted job satisfaction and job burnout. CONCLUSIONS: The current level of job satisfaction is relatively low, job satisfaction has a negative effect on job burnout.
