摘要：
Proprotein convertase subtilisin/kexin 9 (PCSK9), a member of the protein-converting enzyme family, is highly expressed in adult hepatocytes and small intestinal enterocytes. To our knowledge, in this study, we demonstrate for the first time that PCSK9 is upregulated in a dose-dependent manner via oxidized low-density lipoprotein (oxLDL) stimulation in THP-1-derived macrophages. PCSK9 small interfering RNA (siRNA) suppresses the oxLDL-induced inflammatory cytokine expression in THP-1-derived macrophages. The exposure of macrophages to oxLDL markedly increased the expression of NF-kappa B protein in the nucleus. However, this effect was significantly attenuated by PCSK9 si RNA. These findings indicate that PCSK9 expression is induced by ox LDL, and that PCSK9 si RNA protects against inflammation via the inhibition of NF-kappa B activation in oxLDL-stimulated THP-1-derived macrophages. Our results suggest that PCSK9 may be used as a therapeutic target for the treatment of atherosclerosis since PCSK9 siRNA suppresses oxLDL-induced I kappa B-alpha degradation and NF-kappa B nuclear translocation into THP-1-derived macrophages.
作者机构：
[Zhao, Yuhong; Su, Zeguang] Institute of Electrical Engineering, University of south China, Hengyang, Hunan, China;[Zhang, Yunhui] Eastern Boiler Control Co.,LTD, ShenZhen, China
通讯机构：
[Zhao, Y.] I;Institute of Electrical Engineering, , Hengyang, Hunan, China
会议名称：
2012 2nd international Conference on Materials Science and Information Technology(2012第二届材料科学与信息技术国际会议)(MSIT2012)
会议时间：
2012-08-24
会议地点：
西安
会议论文集名称：
2012 2nd international Conference on Materials Science and Information Technology(2012第二届材料科学与信息技术国际会议)(MSIT2012)论文集
作者：
Shengbing Chen;Yaohui Zhou;Huashan Yuan;Feng Wang
期刊：
2012 2nd International Conference on Remote Sensing, Environment and Transportation Engineering,2012年:1-3
作者机构：
[Shengbing Chen; Yaohui Zhou; Huashan Yuan] School of Urban construction, University of South China, USC, Hunan, Hengyang, China
摘要：
There are high-strength pollutant, water quality fluctuations, organic matter of high toxicity, low biodegradability characteristics for hydrogen peroxide wastewater. Membrane filtration /catalytic oxidation /coagulation-sedimentation process was used to treat hydrogen peroxide wastewater. The results indicate that the effluent concentrations meet the requirements of the First Grade of Wastewater Discharging Standard (GB 8978-1996) when the influent concentrations of COD, SS, iol, pH are 4500 mg.L -1 , 200 mg.L -1 , 600 mg.L -1 , from 2 to 5 respectively.
期刊：
Journal of Convergence Information Technology,2012年7(14):375-385 ISSN：1975-9320
通讯作者：
Wu, D.(QW_1982@126.com)
作者机构：
[Zheng, Jianguo; Wu, Daqing] Glorious Sun School of Business, Management DongHua University, Shanghai, China;[Wu, Daqing] Computer Department of University of South China, Hunan, China
摘要：
Particle swarm optimization (PSO) algorithm has been widely applied in many scientific and engineering fields. However, the success of PSO in solving a specific problem crucially depends on appropriately choosing trial vector generation strategies. In this paper, we presented a Multi-strategy adaptive learning PSO (MAPSO) algorithm, in which trial vector generation strategies are gradually self-adapted by learning from their previous experiences in generating promising solutions. At different stages of evolution, different strategies can be determined adaptively to match different phases of the search evolution. The experimental results clearly verify the advantages of MAPSO on the benchmark problems tested. Moreover, a PID parameter optimization problem is used to further evaluate MAPSO. The experimental results show that MAPSO outperforms the other peer algorithms in terms of both the convergence speed and solution accuracy.
