PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappa B activation in THP-1-derived macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Zhihan;Jiang, Lu;Peng, Juan;Ren, Zhong;Wei, Dangheng;...

通讯作者：

Jiang, Zhisheng

作者机构：

[Ren, Zhong; Tang, Zhihan; Wu, Chunyang; Jiang, Zhisheng; Liu, Lushan; Peng, Juan; Jiang, Lu; Wei, Dangheng] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Pan, Lihong] Univ S China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhisheng] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changshcng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Jiang, Zhisheng] U

Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changshcng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

proprotein convertase subtilisin/kexin type 9;macrophages;oxidized low-density lipoprotein;small interfering RNA;inflammatory cytokine

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2012

卷：

期：

页码：

931-938

DOI：

10.3892/ijmm.2012.1072

基金类别：

Key Project of Educational Department of Hunan Province [10A105]; Project of Science and Technology Department of Hunan Province [2009TP4057-2, 2010TP4008-2]; Project of Health Department of Hunan Province [B2011-042]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Proprotein convertase subtilisin/kexin 9 (PCSK9), a member of the protein-converting enzyme family, is highly expressed in adult hepatocytes and small intestinal enterocytes. To our knowledge, in this study, we demonstrate for the first time that PCSK9 is upregulated in a dose-dependent manner via oxidized low-density lipoprotein (oxLDL) stimulation in THP-1-derived macrophages. PCSK9 small interfering RNA (siRNA) suppresses the oxLDL-induced inflammatory cytokine expression in THP-1-derived macrophages. The exposure of macrophages to oxLDL markedly increased the expression of NF-kappa B prote...

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PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappa B activation in THP-1-derived macrophages

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