期刊：
2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11,2009年:2128-+
通讯作者：
Hu, Jiwen
作者机构：
[Hu, Jiwen] Nanhua Univ, Coll Math & Phys, Hengyang 421001, Peoples R China.;[Qian, Shengyou; Hu, Jiwen] Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Peoples R China.
通讯机构：
[Hu, Jiwen] N;Nanhua Univ, Coll Math & Phys, Hengyang 421001, Peoples R China.
会议名称：
The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)
会议时间：
2009-06-11
会议地点：
北京
会议论文集名称：
The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)论文集
关键词：
Subharmonic;dual-driving driving;HIFU therapy;signal-to-noise ratio
摘要：
Cavitation bubbles have aroused mush attention for their significant promise in ultrasonic contrast imaging, targeted therapy and monitoring of high-intensity focused ultrasound (HIFU) therapy. In this paper, a model using a dual-frequency driving pressure for subharmonics generation from cavitation bubbles is constructed. By calculation of the Fourier transformation to the Keller-Milksis equation, we show that bubbles with appropriate radii produce significant subharmonic components within backscatter spectrum. In contrast to the case of single-frequency driving pressure, subharmonics at dual-frequency driving pressure can be generated for higher value of mechanical index (MI) and wider range of initial radii of bubbles. The subharmonic wave is not easy to be absorbed by soft tissues during its propagation compared with higher harmonic wave, and thus subharmonic mode-imaging method for monitoring HIFU therapy maybe has a potential application in providing proper signal-to-noise ratio.
