Synthesis and antifungal activities of novel 5-amino-6-arylamino1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives
作者:
Wang, Hong-Qing*;Zhou, Wei-Pimg;Wang, Yu-Yuan;Lin, Can-Rong
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008年56(16):7321-7325 ISSN:0021-8561
通讯作者:
Wang, Hong-Qing
作者机构:
[Wang, Yu-Yuan; Wang, Hong-Qing; Lin, Can-Rong] Univ S China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Zhou, Wei-Pimg] Univ S China, Coll Math & Phys, Hengyang 421001, Hunan, Peoples R China.;[Wang, Hong-Qing] Univ S China, Coll Chem & Chem Engn, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wang, Hong-Qing] U;Univ S China, Coll Chem & Chem Engn, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
关键词:
1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one;aza-Wittig reaction;synthesis;1,8-2H-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one;antifungal
摘要:
A novel approach was developed to regioselectively synthesize new 5-amino-6-arylamino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 5 derivatives via a tandem aza-Wittig and annulation reactions of iminophosphorane 2, aromatic isocyanates, and hydrazine in 52-92% isolated yields. The compounds 5 reacted with triethyl orthoformate to give 1,8-2H-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a] pyrimidin-4-ones 6 in good yields (62-94%). Their structures were clearly confirmed by spectroscopy data (IR, 1H NMR, MS), elemental analysis, or X-ray diffraction crystallography. The results of preliminary bioassay indicated that the compounds 5 and 6 possessed high antifungal activity against Botrytis cinerea Pers and Sclerotinia sclerotiorum. Compounds 5 showed much better antifungal activities when R was Me instead of PhCH2. Especially, compounds 6c, 6g, and 6i inhibited Sclerotinia by 100% at the concentration of 50 mg/L and by 83, 83, and 82% at the dosage of 10 mg/L, respectively. © 2008 American Chemical Society.
语种:
英文
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化工类专业实践性教学环节的改革与创新教育的研究
作者:
刘慧君;王榆元;袁亚莉;陈仲清
期刊:
化工高等教育,2007年24(6):76-78,102 ISSN:1000-6168
作者机构:
南华大学,化学化工学院,湖南,衡阳,421001;[袁亚莉; 刘慧君; 陈仲清; 王榆元] 南华大学
关键词:
化工专业;创新教育体系;开放性实验室;实践教学;教学特色
摘要:
南华大学化学化工学院在建设"四结合、多层次本科化工教育创新体系"的过程中,加强了实践环节教学,在第二课堂上开展学生课外科技活动的,突出了科研能力的培养,形成了以课堂为主,实验、综合设计、毕业设计和科研项目研究相结合的具有特色的创新教育模式,取得了阶段性成果.
语种:
中文
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利用乳酸菌发酵猕猴桃汁
作者:
王晓晴;王榆元;曾晓雄
期刊:
饮料工业,2006年9(6):20-22 ISSN:1007-7871
作者机构:
南京农业大学食品科技学院,江苏,南京,210095;南华大学化学化工学院,湖南,衡阳,421200
关键词:
乳酸发酵;猕猴桃汁;正交实验
摘要:
以白砂糖、稳定剂为辅助原料,采用驯化的保加利亚乳杆菌和嗜热链球菌发酵猕猴桃汁,通过正交试验,得到产品的最佳工艺:接种量4%,猕猴桃汁∶脱脂乳1∶12、糖10%、时间6h。
语种:
中文
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4-丙基-4′-氰基联苯的合成研究
作者:
王榆元;邓基林;王晓晴
期刊:
中国锰业,2004年22(3):20-22 ISSN:1002-4336
作者机构:
[王榆元] 南华大学;湖南省有色地质勘探局217队;[王晓晴] 南京农业大学;[邓基林] 湖南省有色地勘局
关键词:
4-丙基-4′-氰基联苯;联苯;合成
摘要:
以联苯为原料,经Friedel-Crafts反应、还原反应、碘代反应、氰化反应,合成4-丙基-4'-氰基联苯.此方法合成步骤少,操作简单,提纯方便,节省了费用.
语种:
中文
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