会议论文集名称：
2012 International Symposium on Safety Science and Technology (2012安全科学与技术国际会议)论文集
关键词：
bridge erecting machine tipping;fault tree analysis;minimal path set;structural importance;countermeasure
摘要：
Bridge erecting machine has been widely used nowadays with its efficiency, while just as a coin has two sides, it also brings problem. If a rollover happens, it will lead to equipment damage, casualties or other disastrous accidents. How could technicians take measures to prevent accidents as efficiently as possible? Question remains unsaved. Based on the analysis of “10.26” bridge erecting machine tipping accident, this paper gives a qualitative analysis on the accident by using fault tree analysis. Firstly, fault tree diagram for the bridge erecting machine tipping, namely the causal and generalization relation between events is formulated. All the basic events that influence the way and the degree of the accident are identified, and these can be ascribed to the following three aspects: manufacturing defect, personnel operating error and management oversight. In terms of management oversight, the responsibility of construction unit, safety supervision department and supervision unit are of great importance. Secondly, combining the minimal path set with the structure importance, we conduct a qualitative analysis on the personnel casualties resulted from the accident, thus seek critical approaches to accident prevention. Finally corresponding safety control measures are put forward. It is noteworthy that the approach can be applied in the similar accidents entirely.
期刊：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2012年29(5):946-956 ISSN：1107-3756
通讯作者：
Tang, Chao-Ke
作者机构：
[Zhao, Guo-Jun; Lv, Yun-Cheng; Jiang, Zhi-Sheng; Tang, Chao-Ke; Yin, Kai; Ouyang, Xin-Ping; Jiang, Jin; Mo, Zhong-Cheng] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.;[Fu, Yuchang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
通讯机构：
[Tang, Chao-Ke] U;Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
关键词：
atherosclerosis;epigallocatechi n-3-gallate;ATP-binding membrane cassette transporter A1;Nrf2/Keap1 pathway;nuclear factor-kappa B
摘要：
The ATP-binding membrane cassette transporter A1 (ABCA1) plays a protective role in the development of atherosclerosis for the reverse cholesterol transport process. Epigallocatechin-3-gallate (EGCG), which exists abundantly in green tea, exerts an anti-atherosclerotic effect via anti-inflammatory and metabolic regulation activities. Many genes and proteins related to lipid metabolism are involved in the lowering cholesterol effects of EGCG. However, effects of EGCG on ABCA1 have rarely been described. In the study presented here, we found that exposure of macrophage foam cells to TNF-α results in a downregulation of ABCA1 and a decrease in cholesterol efflux to apoA1, which is attenuated by pretreatment with EGCG. Moreover, rather than activating the Liver X receptor (LXR) pathway, inhibition of the TNF-α-induced nuclear factor-κB (NF-κB) activity is detected with EGCG treatment in cells. In order to inhibit the NF-κB activity, EGCG can promote the dissociation of the nuclear factor E2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) complex; when the released Nrf2 translocates to the nucleus and activates the transcription of genes containing an ARE element inhibition of NF-κB occurs and Keap1 is separated from the complex to directly interact with IKKβ and thus represses NF-κB function. These results provide novel insight into the anti-inflammatory effects of EGCG, as well as the identification of a novel potential therapeutic role for the prevention of atherosclerosis.
