Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies

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成果类型：

期刊论文

作者：

Zeng, Lin;Li, Yan;Hong, Chang;Wang, Jiaren;Zhu, Hongbo;...

通讯作者：

Liu, Li;Xiao, LS;Liu, L;Zhu, H

作者机构：

[Liu, Li; He, Jingzhe; Wang, Jiaren; Xiao, LS; Li, Ruining; Li, Qimei; Zeng, Lin; Liu, L; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Viral Hepatitis Res, Dept Infect Dis, Guangzhou 510515, Peoples R China.

[Ma, Pengcheng; Liu, Li; Zeng, Lin; Liu, L] Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou 510515, Peoples R China.

[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Hong; Zhu, H] Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Peoples R China.

通讯机构：

[Xiao, LS ; Liu, L ; Liu, L; Zhu, H ] S

Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Viral Hepatitis Res, Dept Infect Dis, Guangzhou 510515, Peoples R China.

Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou 510515, Peoples R China.

Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Peoples R China.

语种：

英文

关键词：

Bone mineral density;Hepatic steatosis;Metabolic dysfunction-associated fatty liver disease;Metabolism;Osteoporosis

期刊：

Osteoporosis International

ISSN：

0937-941X

年：

2024

卷：

期：

页码：

679-689

DOI：

10.1007/s00198-023-06996-0

基金类别：

This work was supported by National Key Research and Development Program of China (No.2021YFC2500805, 2020YFC2006400), the National Nature Science Foundation of China (No.81972897,82172751), Guangzhou Science and Technology Project (No.202201011183), and GuangDong Basic and Applied Basic Research Foundation (No.2022A1515110656). This research has been conducted using the UK Biobank (under application number 92668) and NHANES resource. We thank all the participants for their selfless contributions to the study. We thank all the genetics consortiums for making the GWAS summary data publicly available.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Previously observational studies did not draw a clear conclusion on the association between fatty liver diseases and bone mineral density (BMD). Our large-scale studies revealed that MAFLD and hepatic steatosis had no causal effect on BMD, while some metabolic factors were correlated with BMD. The findings have important implications for the relationship between fatty liver diseases and BMD, and may help direct the clinical management of MAFLD patients who experience osteoporosis and osteopenia. PURPOSE: Liver and bone are active endocrine organs with several metabolic functions. However, the ...

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Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies

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