Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Xiaoling;Liu, Yiming;Wu, Junting;Liu, Yu;Liu, Wenjie;...

通讯作者：

Yang, Fengrui

作者机构：

[Hu, Xiaoling; Liu, Yu; Wu, Junting; Yang, Fengrui; Liu, Wenjie] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yiming] Univ South China, Affiliated Nanhua Hosp, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Ji] Univ South China, Affiliated Hosp 1, Dept Endocrinol, Hengyang 421001, Hunan, Peoples R China.

[Yang, Fengrui] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA.

通讯机构：

[Yang, Fengrui] U

Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

P2X7 receptor (P2X7R);Amygdala;Neuropathic pain;Microglia;Astrocytes

期刊：

Brain, Behavior, and Immunity

ISSN：

0889-1591

年：

2020

卷：

页码：

507-514

DOI：

10.1016/j.bbi.2020.04.030

基金类别：

We express thanks to the staff and management of The First Affiliated Hospital of University of South China for creating necessary facilities for the work. We also thank our funding agencies i.e. National Natural Science Foundation of China and Natural Science Foundation of Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The amygdala circuitry and P2X7 receptor (P2X7R) have both been shown to play important roles in the modulation of neuropathic pain (NP). However, little is known about the functional role of P2X7R in the amygdala for the regulation of NP. This study aims to evaluate the alleviative effect of intra-amygdala microinfusion of a pharmacological antagonist of P2X7R (A-438079) on NP and explore its possible mechanism of action. Male Sprague-Dawley rats were used to construct the animal model of NP through spared nerve injury (SNI). The SNI rats rand...

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Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats

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