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Palladium-Catalyzed Long-Range Isomerization of Aryl Olefins

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成果类型:
期刊论文
作者:
Ge, Qianyi;Meng, Jingjie;Liu, Huikang;Yang, Zehua;Wu, Zhengxing;...
通讯作者:
Yang, Z.;Wu, Z.;Zhang, W.
作者机构:
[Ge, Qianyi; Yang, Zehua] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Inst Pharm & Pharmacol, Sch Pharmaceut Sci,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
[Wu, Zhengxing; Zhang, Wanbin; Meng, Jingjie; Liu, Huikang] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
通讯机构:
[Zehua Yang] H
[Zhengxing Wu; Wanbin Zhang] S
Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Institute of Pharmacy & Pharmacology School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001 China<&wdkj&>Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 China
语种:
英文
关键词:
1,2-Hydrogen shift;Aryl olefin;Isomerization;Long-range;Palladium
期刊:
中国化学
ISSN:
1001-604X
年:
2022
卷:
40
期:
19
页码:
2269-2275
基金类别:
We would like to thank the Research Foundation of Education Bureau of Hunan Province (No. 19K079) and the National Key R&D Program of China (No. 2018YFE0126800) for financial support. We thank the Instrumental Analysis Center of SJTU for characterization.
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
Long-range olefin isomerization could lead to the remote functionalization of hydrocarbon chains, which is advantageous with regards to atom-, step-, and redox economy. However, present methodologies for long-range olefin isomerization are mainly focused on heteroatom directed remote olefin migration; studies using aryl groups as the directing group are limited. The limited examples either utilize aryl olefins with special substituted groups on a benzene ring, or use elaborately optimized ligands or co-catalysts to accelerate the isomerization....

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