期刊论文

Expression of human placental form of glutathione S-transferase (GST-π) in human gastric carcinoma and precancerous lesion

中文

武警医学

1004-3594

1998

09

9

497-499

本校为第一机构

为进一步证实人胎盘谷胱甘肽S转移酶与胃癌发生发展的关系,应用S-P法免疫组化技术检测了胃癌和胃癌前病变组织的人胎盘型谷胱甘肽S转移酶(GST-π)的表达.结果提示,胃癌组织中77.6%(45/58)GST-π表达阳性,其中高分化腺癌、低分化腺癌、未分化腺癌、粘液腺癌和印戒细胞癌的阳性率分别为83.3%(10/12)、89.3%(25/28)、66.7%(6/9)、25.0%(1/4)和60.0%(3/5);胃粘膜肠上皮化生和不典型增生病变组织中GST-π阳性率分别为76.0%(19/25)和89.3%(25/28).正常胃粘膜组织中仅10.3%(4/39)呈微弱阳性.GSt-π在胃癌及癌前病变组织中的表达较正常胃粘膜高(P

GST-π was detected in human gastric carcinoma and precancerous lesion by immunohistochemical technique (S-P method). It was shown that 77 6%(45/58) of gastric carcinoma, 76 0%(19/25) of intestinal metaplasia and 89 3%(25/28) of atypical hyperplasia were positively stained immunohistochemically, while most of 39 normal gastric mucosas were negative, with only 4(10 3%) weakly positive. The positive rates of well-differentiated adenocarcinoma, poorly-differentiated adenocarcinoma, undifferentiated adenocarcinoma, mucoid carcinoma and signet ring ...