Identifying the Novel Gut Microbial Metabolite Contributing to Metabolic Syndrome in Children Based on Integrative Analyses of Microbiome-Metabolome Signatures

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Jia;Dai, Wen;Pan, Xiongfeng;Zhong, Yan;Xu, Ningan;...

通讯作者：

Luo, Jiayou;Luo, MY

作者机构：

[Li, Jina; Luo, MY; Ye, Ping; Luo, Jiayou; Wang, Jie; Pan, Xiongfeng; Dai, Wen; Luo, Miyang; Wei, Jia; Luo, JY; Yang, Fei] Xiangya Sch Publ Hlth, Cent South Univ, Changsha, Hunan, Peoples R China.

[Li, Jina; Luo, MY; Ye, Ping; Luo, Jiayou; Wang, Jie; Pan, Xiongfeng; Dai, Wen; Luo, Miyang; Wei, Jia; Luo, JY; Yang, Fei] Cent South Univ, Hunan Prov Key Lab Clin Epidemiol, Changsha, Hunan, Peoples R China.

[Xu, Ningan; Zhong, Yan] Hunan Childrens Hosp, Inst Children Hlth, Changsha, Hunan, Peoples R China.

[Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typical Environm Pollut & Hlth, Hengyang, Hunan, Peoples R China.

通讯机构：

[Luo, MY ; Luo, JY] X

Xiangya Sch Publ Hlth, Cent South Univ, Changsha, Hunan, Peoples R China.

Cent South Univ, Hunan Prov Key Lab Clin Epidemiol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

metabolic syndrome;children;microbiota;metabolites;lipid metabolism;inflammation

期刊：

MICROBIOLOGY SPECTRUM

ISSN：

2165-0497

年：

2023

卷：

期：

页码：

e0377122

DOI：

10.1128/spectrum.03771-22

基金类别：

National Natural Science Foundation [81872641]; Hunan Province Natural Science Foundation [2021JJ30901, 2022JJ40668]; Fundamental Research Funds for the Central Universities of Central South University [2022ZZTS0846]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Metabolic syndrome (MS) has become a health concern worldwide. Gut microbiota and metabolites play an important role in human health. The pathogenesis of gut microbiota and their metabolites in the development of metabolic syndrome (MS) remains unclear. This study aimed to evaluate the signatures of gut microbiota and metabolites as well as their functions in obese children with MS. A case-control study was conducted based on 23 MS children and 31 obese controls. The gut microbiome and metabolome were measured using 16S rRNA gene amplicon sequencing and liquid chromatography-mass spectrometry....

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Identifying the Novel Gut Microbial Metabolite Contributing to Metabolic Syndrome in Children Based on Integrative Analyses of Microbiome-Metabolome Signatures

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