期刊论文

Study on dosimetric changes between initial and second treatment plans in IMRT for large volume NSCLC

中文

中华放射肿瘤学杂志

1004-4221

2020

29

10

872-876

10.3760/cma.j.cn113030-20190227-00066

山东省重点研发计划(2018GSF118006)。

本校为其他机构

目的:采用刚性配准和形变配准方法获得大体积非小细胞肺癌(NSCLC) IMRT中靶区和危及器官(OAR)的累加剂量，并与初次计划的剂量进行比较。方法:选择30例采用IMRT的大体积NSCLC患者，每位患者分别在放疗前和放疗20分次时进行4DCT模拟定位，基于初次4DCT的平均密度投影CT 1-avg制定放疗计划为Plan 1，基于二次4DCT的平均密度投影CT 2-avg修改放疗计划为Plan 2，分别采用刚性配准和形变配准方法将两次计划进行剂量累加得到Plan 刚性和Plan 形变。比较初次定位和二次定位之间大体肿瘤体积(GTV，以吸气末时相图像CT50%上的勾画为准)和OAR (OAR，以平均密度投影图像CT avg上的勾画为准)的体积变...

Objective:To evaluate the cumulative dose of the target volume and organs at risk (OARs) in intensity-modulated radiation therapy (IMRT) for large volume non-small cell lung cancer (NSCLC) based on rigid and deformation registration methods. The dosimetric changes between the initial and second treatment plans were compared.Methods:Thirty patients treated with IMRT for large volume NSCLC with twice 4DCT scans acquired before radiotherapy and after 20 fractions of radiotherapy were recruited. The initial treatment plan (Plan 1) based on the average density projection CT (CT 1-avg) of the firs...