期刊论文

A study of finite discontinuity-volumetric modulated arc therapy for mid-and distal-Esophageal Carcinoma

中文

中华放射肿瘤学杂志

1004-4221

2016

25

11

1238-1243

10.3760/cma.j.issn.1004-4221.2016.11.020

天津医科大学肿瘤医院药检放专项基金（Y1407） 国家自然科学基金（81201753）

本校为其他机构

目的实现Pinnacle计划系统VMAT弧内间断出束的功能,并探究其临床应用优势。方法选取本院8例胸中下段食管癌病例。通过编写的程序实现Pinnacle弧内间断出束的VMAT(FD-VMAT)。每个病例均设计FD-VMAT、VMAT和固定野IMRT计划。计划评价参数包括PTV的CI、HI、OAR受量、计划验证通过率、机器跳数和治疗时间。配对t检验比较不同计划间差别。结果FD-VMAT计划PTV的CI值和VMAT基本等同(P = 0.186),HI值略差于VMAT (P=0.001),但均优于IMRT计划(P = 0.006、0.002)。FD-VMAT肺的V_(20)、V_(30)保持了VMAT的优点,比IMRT分别降低19.8%(P=0.000)和20.3%(P=0.000);但FD-VMAT肺≤ V_5具备IMRT的优点,受量低于VMAT,...

Objective To implement the finite discontinuity-volumetric modulated arc therapy (FD-VMAT) in the Pinnacle planning system, and to investigate its clinical significance. Methods Eight patients with thoracic esophageal cancer in our hospital were enrolled as subjects. FD-VMAT was fulfilled in the Pinnacle planning system using a developed program. FD-VMAT, VMAT, and fixed-field intensity-modulated radiotherapy (IMRT) plans were designed for each patient. The conformity index (CI) and homogeneity index (HI) of the planning target volume (PTV),dos...