TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Zhi-Xiang;Ma, Xiao-Feng;Xiong, Wen-Hao;Ren, Zhong;Jiang, Miao;...

通讯作者：

Jiang, ZS;Zheng, H

作者机构：

[Zhou, Kun; Xiong, Wen-Hao; Deng, Nian-Hua; Zhou, Zhi-Xiang; Jiang, Miao; Jiang, Zhi-Sheng; Ren, Zhong; Jiang, ZS; Liu, Hui -Ting; Zhou, Bo -Bin] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerosis Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Ma, Xiao-Feng] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Hu, Heng-Jing] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Zheng, He] Univ South China, Cent Hosp Shaoyang City, Dept Hepatobiliary Surg, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

[Zheng, He] Univ South China, Hengyang Med Sch, Affiliated Shaoyang Hosp, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

通讯机构：

[Jiang, ZS ; Zheng, H ] U

Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerosis Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Cent Hosp Shaoyang City, Dept Hepatobiliary Surg, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

Univ South China, Hengyang Med Sch, Affiliated Shaoyang Hosp, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

语种：

英文

关键词：

ApoE(−/−) mice;Atherosclerosis;Phenotypic transformation;Signal pathway;Tripartite motif (TRIM65);VSMCs

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2024

卷：

390

页码：

117430

DOI：

10.1016/j.atherosclerosis.2023.117430

基金类别：

Fianancial support This work was supported by the National Key Research and Development Program of China (2019YFA0801601 to ZSJ), the National Natural Science Foundation of China (81670429, 91839103 to ZSJ), Special for Construction of Innovative Provinces in Hunan Province (2020SK2105 to ZSJ), International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (2018WK4031), “Double First-Class” project for innovative Group of Basic Medicine, University of South China (to ZSJ), Key CRediT authorship contribution statement Zhi-Xiang Zhou: Conceptualization, Project administration, Validation, Visualization, Formal analysis, Data curation, Investigation, Methodology, Writing – original draft. Xiao-Feng Ma: acquisition, Investigation. Wen-Hao Xiong: Formal analysis. Zhong Ren: Resources. Miao Jiang: Resources. Nian-Hua Deng: Resources. Bo-Bin Zhou: collected tissue samples. Hui-Ting Liu: Writing – review & editing. Kun Zhou: collected tissue samples. Heng-Jing Hu: Resources. Hui-Fang Tang: Writing – review

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND AND AIMS: Tripartite motif (TRIM65) is an important member of the TRIM protein family, which is a newly discovered E(3) ligase that interacts with and ubiquitinates various substrates and is involved in diverse pathological processes. However, the function of TRIM65 in atherosclerosis remains unarticulated. In this study, we investigated the role of TRIM65 in the pathogenesis of atherosclerosis, specifically in vascular smooth muscle cells (VSMCs) phenotype transformation, which plays a crucial role in formation of atherosclerotic le...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问