PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Bo-jie;Chen, Hao;Jiang, Su-su;Wang, Chu-yao;Tuo, Qin-hui;...

通讯作者：

Long, Shi-yin;Zhang, Cai-ping

作者机构：

[Wang, Chu-yao; Long, Shi-yin; Long, SY; Zhang, Cai-ping; Li, Bo-jie; Jiang, Su-su] Univ South China, Dept Biochem & Mol Biol, Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Chen, Hao] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Tuo, Qin-hui] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Liao, Duan-fang] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Long, SY; Zhang, CP] U

Univ South China, Dept Biochem & Mol Biol, Med Coll, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

KIF16B;Kinesin;Endocytic trafficking;Cholesterol transport

期刊：

JOURNAL OF MEMBRANE BIOLOGY

ISSN：

0022-2631

年：

2020

卷：

253

期：

页码：

101-108

DOI：

10.1007/s00232-020-00110-9

基金类别：

This study was funded by National Nature Science Fund of China (Grant nos. 81600291, 81673722), Nature Science Fund of Hunan province (Grant nos. 2018JJ2348, 2018JJ2346), Hunan Provincial Innovation Foundation for Postgraduate (Grant No. CX2018B62), and the construct program of the Pharmaceutical Science key discipline in Hunan province.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport of intracellular cargo and the formation of endosomal tubules. Ras-related protein (Rab) coordinates many steps of membrane transport and are involved in the regulation of KIF16B-mediated vesicle trafficking...

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