期刊论文

Study on PFOS's Liver Toxicity and Lycopene's Protection Function in SD Rats

中文

长沙医学院学报

2013

4

33-37

本校为第一机构

目的观察全氟辛烷磺酸(PFOS)和番茄红素(LP)对大鼠肝脏毒性的影响。方法将成年SD大鼠48只随机分为8组:溶剂对照组、低、中、高剂量PFOS染毒组、LP组、LP保护低、中、高剂量PFOS染毒组:溶剂对照组进食2%Tween-80处理后的普通饲料,低、中、高PFOS染毒组分别进食5、25、125 ms/kg PFOS染毒饲料,LP组和LP保护低、中、高剂量PFOS染毒组灌胃LP(20ms/kg),每天一次,每周连续5天,连续2个月:末次染毒24h后,眼眶静脉丛取血后处死大鼠,测定各组大鼠的肝脏功能指标的变化。结果中、高剂量PFOS组大鼠肝脏脏器系数高于溶剂对照组(P【0.05),LP保护中、高剂量PFOS组肝脏脏器系数与相同剂量PFOS染毒组相比降低(P【...

Objective To study the liver toxicity of the perfluorooetane sulfonate(PFOS) and the lyeopene's(LP) pmtection function in rat.Method 48 healthy SD rats were averagely divided into 8 groups randomly including control group,The control group was fed fodder dealed with 2%Tween-80.PFOS groups.LP group was fed lycopeme.LP protected groups were fed PFOS as the sanle does and lyeopene,respectively for 2 months.Blood was taken from venous plexus of rats' eye sockets and then they were killed.Th e changes of rats' s liver functional parameter in each gr...