Network pharmacology analysis reveals potential targets and mechanisms of proton pump inhibitors in breast cancer with diabetes

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成果类型：

期刊论文

作者：

Hu, Haihong;Wang, Hanbin;Yang, Xiaoyan;Li, Zhicheng;Zhan, Wendi;...

通讯作者：

Zhang, TL

作者机构：

[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, HongXia] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421000, Hunan, Peoples R China.

[Zhang, Taolan; Yang, Xiaoyan; Hu, Haihong; Zhan, Wendi; Li, Zhicheng; Zhang, TL; Wang, Hanbin; Zhu, HongXia] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan; Zhang, TL] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Chinese Tradit Med CTM Res Platform Major Epidem T, Hengyang 421000, Hunan, Peoples R China.

通讯机构：

[Zhang, TL ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421000, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Chinese Tradit Med CTM Res Platform Major Epidem T, Hengyang 421000, Hunan, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2023

卷：

期：

页码：

7623

DOI：

10.1038/s41598-023-34524-x

基金类别：

The present study was supported by the National Natural Science Foundation of China (Grant Number 82003802), the Natural Science Foundation of Hunan Province (Grant Number 2019JJ50542), the Science and Technology Program of Hunan Health Commission (Grant Number 20201978), the China Scholarship Council (Grant Number 201808430085) and Clinical Research 4310 Program of the First Affiliated Hospital of the University of South China (Grant Number 20224310NHYCG04), Science and technology innovation Program of Hengyang City (Grant Number 202250045223).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Breast cancer and diabetes are significant health challenges, and effective treatments for both diseases are lacking. Proton pump inhibitors (PPIs) have demonstrated anticancer and hypoglycemic effects, but their mechanisms of action are not yet fully understood. We used the GeneCards and PharmMapper databases to identify therapeutic targets for diabetes, breast cancerand PPIs. We identified common targets and constructed a regulatory network of diseases and drugs using the STRING database and Cytoscape software. We also explored the binding between small molecule ligands and protein receptors...

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Network pharmacology analysis reveals potential targets and mechanisms of proton pump inhibitors in breast cancer with diabetes

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