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Dissecting the role of gut microbiota heterogeneity in the onset of chronic lung diseases

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成果类型:
期刊论文
作者:
Lin, Ya;Zhang, Xiaoxiao;Zuo, Ziyi;Xiao, Yijia
通讯作者:
Xiao, YJ
作者机构:
[Lin, Ya; Zhang, Xiaoxiao; Zuo, Ziyi] Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Wenzhou 325000, Zhejiang, Peoples R China.
[Xiao, Yijia] Univ South China, Affiliated Changsha Cent Hosp, Dept Pulm & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Xiao, YJ ] U
Univ South China, Affiliated Changsha Cent Hosp, Dept Pulm & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
Gut microbiota;Mendelian randomization analysis;Genome-wide association study;Chronic lung diseases;Insilico in-situ microbiota resequencing
期刊:
AMB EXPRESS
ISSN:
2191-0855
年:
2025
卷:
15
期:
1
页码:
1-20
基金类别:
This research was funded by grants from the Health Research Project of the Hunan Provincial Health Commission (No. D202303026282) and the Changsha Natural Science Foundation (Kq2403162).
机构署名:
本校为通讯机构
摘要:
Evidence from observational studies and clinical trials has reported that gut microbiota (GM) was associated with chronic lung diseases (CLDs). However, the causal relationships between GM and CLDs have yet to be fully ascertained. The Mendelian randomization (MR) based causal analysis was performed using the genome-wide association study (GWAS) summary statistics from the MiBioGen and FinnGen consortium. GM served as exposure, and CLDs were taken for outcomes. Inverse variance weighted, MR-Egger, and weighted median methods were utilized to examine the causal association between GM and CLDs. ...

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