期刊论文、会议论文

中文

中国动脉硬化杂志

1007-3949

2011

19

3

197-201

第十一次全国动脉硬化性疾病学术会议暨第七届中国病理生理学会动脉粥样硬化专业委员会、国际动脉粥样硬化学会中国分会全国会员大会

第十一次全国动脉硬化性疾病学术会议暨第七届中国病理生理学会动脉粥样硬化专业委员会、国际动脉粥样硬化学会中国分会全国会员大会论文集

2011-04-01

湖南衡阳

中国病理生理学会动脉粥样硬化专业委员会<&wdkj&>国际动脉粥样硬化学会中国分会<&wdkj&>南华大学

(09010280183):中华医学会临床医学科研专项基金

本校为第一机构

目的观察参松养心胶囊对压力超负荷所致心力衰竭大鼠的QT离散度及缝隙连接蛋白43表达的干预作用。方法采用腹主动脉缩窄法建立大鼠心力衰竭模型，经参松养心胶囊治疗8周。用皮下插入自制电极检测心室电生理变化，经HE染色观察其形态结构变化，Masson染色判断心肌纤维化沉积，免疫组织化学法观察缝隙连接蛋白43在左心室心肌组织的分布。结果心力衰竭大鼠QT离散度明显延长(37.20±9.94 ms，P

Aim To investigate the effect of Shensongyangxin capsule on QT dispersion and connexin43 expression in heart failure rats. Methods Heart failure rats models were built by constricting abdominal aorta,and were lavaged with Shensongyangxin capsule for 8 weeks.Ventricular electrophysiology were measured by inserting home-made electrode into subcutaneous,left ventricular morphostructure,myocardial fibrosis,and connexin43 distribution were respectively observed by HE staining,Masson staining,immunohistochemical staining. Results Heart failure rats...