Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway

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成果类型：

期刊论文

作者：

Yao, Feng;Lv, Yun-Cheng;Zhang, Min;Xie, Wei;Tan, Yu-Lin;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Gong, Duo; Lv, Yun-Cheng; Tang, Chao-Ke; Tan, Yu-Lin; Cheng, Hai-Peng; Li, Liang; Liu, Xiao-Yan; Xie, Wei; Yao, Feng; Zhang, Min; Liu, Dan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

[Yao, Feng] Univ South China, Dept Lab Anim Sci, Hengyang 421001, Hunan, Peoples R China.

[Liu, Xiao-Yan] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol,Hlth Sci Ctr, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apelin-13;Autophagy;Cholesterol efflux;Class III PI3K/Beclin-1;Macrophage foam cells

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2015

卷：

466

期：

页码：

637-643

DOI：

10.1016/j.bbrc.2015.09.045

基金类别：

The research is supported by the National Natural Sciences Foundation of China ( 81300224 , 81370377 , and 81170278 ), the construct program of the key discipline in Hunan province, Zhengxiang Scholar Program of University of South China ( 2014-004 ), Science and Technology Project of Hunan Province ( 2014TT2018 ), and Aid Program for Science and Technology Bureau of Hengyang City ( 2014KJ08 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Apelin-13, an adipokine, promotes cholesterol efflux in macrophages with antiatherosclerotic effect. Autophagy, an evolutionarily ancient response to cellular stress, has been involved in atherosclerosis. Therefore, the purpose of this study was to investigate whether apelin-13 regulates macrophage foam cell cholesterol metabolism through autophagy, and also explore the underlying mechanisms. Here, we revealed that apelin-13 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux. Our study furthe...

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Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway

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