Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration-resistant prostate cancer cells

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成果类型：

期刊论文

作者：

Hsia, Yi-Jan;Lin, Zhang-Min;Zhang, Taolan;Chou, Tz-Chong

通讯作者：

Chou, TC

作者机构：

[Hsia, Yi-Jan] Buddhist Tzu Chi Med Fdn, Dent Dept, New Taipei 23142, Taiwan.

[Hsia, Yi-Jan] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Div Oral & Maxillofacial Surg, New Taipei 23142, Taiwan.

[Chou, Tz-Chong; Lin, Zhang-Min] Cathay Gen Hosp, Cathay Med Res Inst, Lane 160,32 Jiancheng Rd, New Taipei 22174, Taiwan.

[Zhang, Taolan] Univ South China, Dept Pharm, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan] Univ South China, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Chou, TC ] C

Cathay Gen Hosp, Cathay Med Res Inst, Lane 160,32 Jiancheng Rd, New Taipei 22174, Taiwan.

语种：

英文

关键词：

butyrate;glyoxalases;methylglyoxal;nuclear factor erythroid 2‑related factor2;prostate cancer;signal transducer and activator of transcription 3

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2024

卷：

期：

DOI：

10.3892/or.2024.8730

基金类别：

Ministry of Science and Technology, Taiwan, R.O.C.

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Cancer cells are characterized by increased glycolysis, known as the Warburg effect, which leads to increased production of cytotoxic methylglyoxal (MGO) and apoptotic cell death. Cancer cells often activate the protective nuclear factor erythroid 2‑related factor2 (Nrf2)/glyoxalase1 (Glo1) system to detoxify MGO. The effects of sodium butyrate (NaB), a product of gut microbiota, on Nrf2/Glos/MGO pathway and the underlying mechanisms in prostate cancer (PCa) cells were investigated in the present study. Treatment with NaB induced the cell deat...

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Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration-resistant prostate cancer cells

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