Pregnancy-associated plasma protein-A accelerates atherosclerosis by regulating reverse cholesterol transport and inflammation

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成果类型：

期刊论文

作者：

Tang, Shi-Lin;Zhao, Zhen-Wang;Liu, Shang-Ming;Wang, Gang;Yu, Xiao-Hua;...

通讯作者：

Fu, Hui;Tang, Chao-Ke

作者机构：

[Fu, Hui; Liu, Shang-Ming; Tang, Shi-Lin] Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Wang, Si-Qi; Wang, Gang; Tang, Chao-Ke; Zhao, Zhen-Wang; Yu, Xiao-Hua; Zou, Jin] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Expt Ctr, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long; Dai, Xiao-Yan] Guangzhou Med Univ, Key Lab Mol Target & Clin Pharmacol, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.

[Zheng, Xi-Long; Dai, Xiao-Yan] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China.

[Fu, Min-Gui] Univ Missouri, Sch Med, Dept Biomed Sci, Kansas City, MO 64108 USA.

通讯机构：

[Fu, Hui; Tang, Chao-Ke] U

Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Expt Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Inflammation;Pregnancy-associated plasma protein-A;Reverse cholesterol transport

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2019

卷：

期：

页码：

515-523

DOI：

10.1253/circj.CJ-18-0700

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ4076]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]; Hunan Provincial Innovation Foundation for Postgraduate [CX2018B61]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: Recent studies have suggested that pregnancy-associated plasma protein-A (PAPP-A) is involved in the pathogenesis of atherosclerosis. This study aim is to investigate the role and mechanisms of PAPP-A in reverse cholesterol transport (RCT) and inflammation during the development of atherosclerosis. Methods and Results: PAPP-A was silenced in apolipoprotein E (apoE −/− ) mice with administration of PAPP-A shRNA. Oil Red O staining of the whole aorta root revealed that PAPP-A knockdown reduced lipid accumulation in aortas. Oil Red O...

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Pregnancy-associated plasma protein-A accelerates atherosclerosis by regulating reverse cholesterol transport and inflammation

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