期刊论文

Chen, Zhi-Wei

英文

Clinica Chimica Acta

0009-8981

2014

437

78-87

10.1016/j.cca.2014.07.012

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China ( 81170278 , 81370377 and 81300224 ), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province ( 2008-244 ), and the construct program of the key discipline in Hunan Province, China ( 2011-76 ).

本校为第一且通讯机构

Hydrogen sulfide (H2S) is a well-known toxic gas with the characteristic smell of rotten eggs. It is synthesized endogenously in mammals from the sulfur-containing amino acid l-cysteine by the action of several distinct enzymes: cystathionine-γ-lyase (CSE), cystathionine-ß-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) along with cysteine aminotransferase (CAT). In particular, CSE is considered to be the major H2S-producing enzyme in the cardiovascular system. As the third gasotransmitter next to nitric oxide (NO) and carbon...