A novel WD-repeat protein, WDR26, inhibits apoptosis of cardiomyocytes induced by oxidative stress

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成果类型：

期刊论文

作者：

Feng, Yansheng;Zhang, Chi;Luo, Qi;Wei, Xing;Jiang, Bimei;...

通讯作者：

Xiao, Xianzhong

作者机构：

[Xiao, Xianzhong; Zhang, Lingli; Feng, Yansheng; Luo, Qi; Jiang, Bimei; Zhang, Chi; Zhu, Honglin; Liu, Meidong; Jiang, Lei] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410078, Hunan, Peoples R China.

[Wei, Xing; Zhang, Chi] Univ S China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Dept Pathophysiol, Hengyang, Hunan, Peoples R China.

[Xiao, Xianzhong] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Xiao, Xianzhong] C

Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Ischaemia-reperfusion injury;Mitochondria;Oxidative stress;WDR26

期刊：

Free Radical Research

ISSN：

1071-5762

年：

2012

卷：

期：

页码：

777-784

DOI：

10.3109/10715762.2012.678840

基金类别：

All authors of this manuscript disclose any financial and personal relationships with other people or organizations that could have influenced this work. This work was supported by grants from the Major National Basic Research Program of China (no. 2007CB512007), the National Natural Science Foundation of China (81100106) and the Open-End Fund for the Valuable and Precision Instruments of Central South University (2011 - 37, 2011 - 39). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

WD40 repeat proteins have a variety of functions, such as signal transduction, transcription regulation, cell cycle control, autophagy and apoptosis. WDR26 is a novel protein of WD40 repeat proteins and up-regulated during myocardial cells ischemic preconditioning (IPC) but its role in myocardial cell apoptosis induced by oxidative stress and its subcellular localisation are not clear. So we investigated the subcellular localisation of WDR26 and WDR26 expression in rat myocardial ischaemia-reperfusion injury model and H9c2 cells stimulated by H...

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A novel WD-repeat protein, WDR26, inhibits apoptosis of cardiomyocytes induced by oxidative stress

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