Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Guilian;Zhang, Jingrui;Guo, Qian;Wei, Jianhao;Jiang, Yi;...

通讯作者：

Wan, Kanglin

作者机构：

[Zhao, Xiuqin; Zhao, Li-li; Zhang, Jingrui; Jiang, Yi; Liu, Zhiguang; Li, Guilian; Guo, Qian; Wan, Kanglin; Wei, Jianhao] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, TB Branch, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

[Zhao, Xiuqin; Zhao, Li-li; Zhang, Jingrui; Jiang, Yi; Liu, Zhiguang; Li, Guilian; Guo, Qian; Wan, Kanglin; Wei, Jianhao] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China.

[Lu, Jianxin; Zhang, Jingrui; Wei, Jianhao] Wenzhou Med Coll, Key Lab Lab Med, Wenzhou, Zhejiang, Peoples R China.

[Zhang, Jingrui] Lab Gynecol & Obstetr Hosp, Shijiazhuang, Hebei, Peoples R China.

[Guo, Qian] South China Univ, Pathogen Biol Inst, Hengyang, Hunan, Peoples R China.

通讯机构：

[Wan, Kanglin] C

Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, TB Branch, State Key Lab Infect Dis Prevent & Control, POB 5, Beijing 102206, Peoples R China.

语种：

英文

期刊：

JOURNAL OF ANTIBIOTICS

ISSN：

0021-8820

年：

2015

卷：

期：

页码：

431-435

DOI：

10.1038/ja.2015.9

基金类别：

National Key Programme of Mega Infectious Diseases [2013ZX10003002-001]; State Key Laboratory for Infectious Disease Prevention and Control [2014SKLID104]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. This study aimed to determine whether RIF induces efflux pump activation in RIF-monoresistant M. tuberculosis strains. Here, we took advantage of 16 RIF-monoresistant M. tuberculosis clinical isolates to evaluate the expression of 27 putative drug efflux pump genes and measured the influence of four drug efflux pump inhibitors, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), verapamil...

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Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates

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