RORalpha Suppresses Epithelial-to-Mesenchymal Transition and Invasion in Human Gastric Cancer Cells via the Wnt/beta-Catenin Pathway.

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成果类型：

期刊论文

作者：

Su, Jian;Su, Bo;Xia, Hong;Liu, Fang;Zhao, Xiaohong;...

通讯作者：

Su, Qi;Wu, Youhua

作者机构：

[Su, Bo; Su, Qi; Li, Juan; Zhang, Jizhen; Ling, Hui; Shi, Ying; Zhao, Xiaohong; Su, Jian; Zeng, Ying; Xia, Hong; Liu, Fang; Zang, Xi] Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.

[Su, Jian] Univ South China, Affiliated Hosp 2, Dept Pathol, Hengyang, Peoples R China.

[Su, Bo] Univ South China, Inst Pharm & Pharmacol, Key Lab Pharmacoprote Hunan Prov Univ, Hengyang, Peoples R China.

[Su, Qi; Ling, Hui; Wu, Youhua; Wu, YH; Su, Q; Zeng, Ying; Xia, Hong; Liu, Fang; Zang, Xi] Univ South China, Affiliated Hosp 2, Ctr Gastr Canc Res Hunan Prov, Hengyang, Peoples R China.

[Zhao, Xiaohong] Hainan Maternal & Child Hlth Hosp, Dept Gynaecol, Haikou, Hainan, Peoples R China.

通讯机构：

[Su, Qi; Wu, YH; Su, Q] U

Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.

Univ South China, Affiliated Hosp 2, Ctr Gastr Canc Res Hunan Prov, Hengyang, Peoples R China.

语种：

英文

关键词：

RORalpha;Wnt/beta-catenin pathway;epithelial-to-mesenchymal transition;human gastric cancer;invasion;proliferation

期刊：

FRONTIERS IN ONCOLOGY

ISSN：

2234-943X

年：

2019

卷：

页码：

1344

DOI：

10.3389/fonc.2019.01344

基金类别：

This work was supported by The National Natural Scientific Foundation of China (Nos. 81374013, 81641112, 81101643, 31100935, and 81102854), The Patency Foundation of Innovation Platform of Hunan Provincial University of China (No. 09K074), The Scientific Research Foundation of Health and Family Planning Committee of Hunan Province (No. B2015-182), and The Construct Program of the Key Discipline in Hunan Province of China (No. 2011-76).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Retinoid-related orphan receptor alpha (RORalpha) is involved in tumor development. However, the mechanisms underlying RORalpha inhibiting epithelial-to-mesenchymal transition (EMT) and invasion are poorly understood in gastric cancer (GC). This study revealed that the decreased expression of RORalpha is associated with GC development, progression, and prognosis. RORalpha suppressed cell proliferation, EMT, and invasion in GC cells through inhibition of the Wnt/beta-catenin pathway. RORalpha overexpression resulted in the decreased Wnt1 expression and the increased RORalpha interaction with be...

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RORalpha Suppresses Epithelial-to-Mesenchymal Transition and Invasion in Human Gastric Cancer Cells via the Wnt/beta-Catenin Pathway.

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