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Long-Term Exposure to Microcystin-LR Induces Gastric Toxicity by Activating the Mitogen-Activated Protein Kinase Signaling Pathway

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成果类型:
期刊论文
作者:
Liu, Ying;Li, Yafang;Tan, Qinmei;Lv, Yilin;Tang, Yan;...
通讯作者:
Yao, Xueqiong;Yang, F
作者机构:
[Liu, Ying; Lv, Yilin; Yao, Xueqiong; Tan, Qinmei; Yao, XQ; Yang, F; Li, Yafang; Yang, Fei; Tang, Yan] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421009, Peoples R China.
[Yang, F; Yang, Fei; Yang, Yue] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Peoples R China.
[Yang, F; Yang, Fei] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Lab Ecol Environm & Crit Human Dis Prevent Hunan P, Hengyang 421009, Peoples R China.
通讯机构:
[Yao, XQ; Yang, F ] U
Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421009, Peoples R China.
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Peoples R China.
Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Lab Ecol Environm & Crit Human Dis Prevent Hunan P, Hengyang 421009, Peoples R China.
语种:
英文
关键词:
MC-LR;gastric toxicity;inflammation;MAPK signaling pathway;mitophagy
期刊:
TOXINS
ISSN:
2072-6651
年:
2023
卷:
15
期:
9
页码:
574-
基金类别:
Conceptualization, Y.L. (Ying Liu), Y.L. (Yafang Li) and Y.Y.; Methodology, Y.L. (Ying Liu) and Y.L. (Yafang Li); software, Q.T.; validation, Y.L. (Yilin Lv) and Y.T.; Formal analysis, Y.T.; investigation, Y.Y.; resources, Y.Y.; Data curation, Y.L. (Ying Liu) and Y.L. (Yafang Li); Writing—original draft, Y.L. (Ying Liu), X.Y. and Y.L. (Yafang Li); Writing—review and editing, Y.L. (Ying Liu), X.Y., Y.L. (Yafang Li) and F.Y.; Supervision, F.Y.; Funding acquisition, X.Y. and F.Y. All authors have read and agreed to the published version of the manuscript. This research was funded by the Key Research and Development Projects in Hunan Province (2022SK2089, 2019SK2041), the Huxiang Youth Talent Program (2021RC3107), the Research Foundation of Education Bureau of Hunan Province, China (22A0300), the Natural Science Foundation of Hunan Province (2023JJ40569), National College Students’ innovation and entrepreneurship training program, China, (202110555010). We thank Figdraw (www.figdraw.com (accessed on 11 June 2023)) for expert assistance in the pattern drawing.
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Previous studies have primarily concentrated on the hepatotoxicity of MC-LR, whereas its gastric toxicity effects and mechanisms of long-term exposure under low dosage remain unknown. Herein, the gastric tissue from C57BL/6 mice fed with drinking water contaminated by low-dose MC-LR (including 1, 60, and 120 μg/L) was investigated. The results obtained showed that exposure to different concentrations of MC-LR resulted in significant shedding and necrosis of gastric epithelial cells in mice, and a down-regulation of tight junction markers, incl...

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