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A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases

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成果类型:
期刊论文
作者:
Zhang, Jia;Xiao, Li;Yin, Yufang;Sirois, Pierre;Gao, Hanlin;Li, Kai*
通讯作者:
Li, Kai
作者机构:
[Xiao, Li; Zhang, Jia] Soochow Univ, Affiliated Hosp 2, Clin Mol Diagnost Ctr, Suzhou 215004, Peoples R China.
[Yin, Yufang] Univ S China, SNP Inst, Henyang 421001, Peoples R China.
[Sirois, Pierre] Univ Sherbrooke, Dept Pharmacol, Sherbrooke, PQ J1H 5N4, Canada.
[Gao, Hanlin] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA.
[Li, Kai] Soochow Univ, Coll Med, Dept Pharmacol, Suzhou 215123, Peoples R China.
通讯机构:
[Li, Kai] Soochow Univ, Coll Med, Dept Pharmacol, Suzhou 215123, Peoples R China.
语种:
英文
关键词:
Indels;Cancer;Length distribution
期刊:
Applied Biochemistry and Biotechnology
ISSN:
0273-2289
年:
2010
卷:
162
期:
2
页码:
321-328
基金类别:
Department of Personnel Jiangsu province "Liu Da Ren Cai Gao Feng" [07-B-033]; The National Natural Science Foundation of China [30970877]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.

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